Metabolic

New Research Indicates That Insulin Spike After Eating Is Actually a Good Thing

Researchers have conducted a study revealing that post-meal insulin surges might indicate good metabolic health, challenging the previously held belief that they are harmful. The study, which focused on long-term cardiometabolic implications in new mothers, found that higher corrected insulin response (CIR) levels are associated with better beta-cell function and a reduced risk of developing pre-diabetes or diabetes. This research could reshape the understanding of insulin’s role in metabolism and weight management.

The research challenges the idea that an insulin surge after eating is harmful.

Researchers at Sinai Health have discovered important insights into the link between post-meal {"@context":"http:\/\/schema.org","@type":"Article","dateCreated":"2024-01-29T21:20:05+00:00","datePublished":"2024-01-29T21:20:05+00:00","dateModified":"2024-01-29T21:20:05+00:00","headline":"New Research Indicates That Insulin Spike After Eating Is Actually a Good Thing","name":"New Research Indicates That Insulin Spike After Eating Is Actually a Good Thing","keywords":[],"url":"https:\/\/dailyzhealthpress.com\/new-research-indicates-that-insulin-spike-after-eating-is-actually-a-good-thing\/","description":"Researchers have conducted a study revealing that post-meal insulin surges might indicate good metabolic health, challenging the previously held belief that they are harmful. The study, which focused","copyrightYear":"2024","articleSection":"Metabolic","articleBody":"Researchers have conducted a study revealing that post-meal insulin surges might indicate good metabolic health, challenging the previously held belief that they are harmful. The study, which focused on long-term cardiometabolic implications in new mothers, found that higher corrected insulin response (CIR) levels are associated with better beta-cell function and a reduced risk of developing pre-diabetes or diabetes. This research could reshape the understanding of insulin\u2019s role in metabolism and weight management.The research challenges the idea that an insulin surge after eating is harmful.Researchers at Sinai Health have discovered important insights into the link between post-meal insulin levels and long-term cardiac and metabolic well-being. This study challenges the prevailing belief that an insulin spike after eating is a bad thing.On the contrary \u2013 it could be an indicator of good health to come.Led by Dr. Ravi Retnakaran, Clinician-Scientist at the Lunenfeld-Tanenbaum Research Institute, part of Sinai Health, the study set out to explore how insulin levels after meals impact cardiometabolic health. While past research has yielded conflicting results, suggesting both harmful and beneficial effects, this new study aimed to provide a clearer picture over an extended period of time.The team reported their findings in the online journal eClinicalMedicine, published by the Lancet group.Understanding Insulin\u2019s RoleNormally, insulin levels rise after eating to help manage blood sugar. However, the concern is whether a rapid increase in insulin after a meal could spell bad health. Some believe the insulin surge, especially after eating carbs, promotes weight gain and contributes to insulin resistance. This occurs when the body\u2019s cells don\u2019t respond well to insulin, making it harder to control blood sugar levels and increasing the risk of type 2 diabetes.\u201cThe suggestion has been made by some people that those insulin peaks have deleterious effects by promoting weight gain,\u201d said Dr. Retnakaran, who is also Endocrinologist at the Leadership Sinai Centre for Diabetes at Mount Sinai Hospital where he holds the Boehringer Ingelheim Chair in Beta-cell Preservation, Function and Regeneration. He is also a Professor at the University of Toronto\u2019s Temerty Faculty of Medicine.\u201cSometimes I see patients in the clinic who have adopted this notion, maybe from the internet or what they\u2019re reading, that they can\u2019t have their insulin level go too high,\u201d he said.The science is just not conclusive enough to support this notion. Most studies on this topic were either conducted over a short period of time or were based on insulin measurements in isolation that are inadequate and can be misleading, said Dr. Retnakaran.Methodology and ParticipantsHis team sought to address this problem by looking at cardiometabolic implications of insulin response over the long term, and in a way that accounts for baseline blood sugar levels. The latter point is key because each person has an individual insulin response that varies depending on how much sugar is in the blood.The study followed new mothers because the insulin resistance that occurs during pregnancy makes it possible to determine their future risk of type 2 diabetes. 306 participants were recruited during pregnancy, between 2003 and 2014, and underwent comprehensive cardiometabolic testing, including glucose challenge tests, at one, three, and five years after giving birth. The glucose challenge test measures glucose and insulin levels at varying time points after a person has had a sugary drink containing 75 grams of glucose and following a period of fasting.Implications and Future DirectionsWhile commonly used in medical practice, the interpretation of insulin levels from the test can be misleading if one does not account for baseline blood sugar. \u201cIt\u2019s not just about insulin levels; it\u2019s about understanding them in relation to glucose,\u201d Dr. Retnakaran said, pointing out that this is where many past interpretations fell short. A better measurement is the corrected insulin response (CIR) that accounts for baseline blood glucose levels, and which is slowly gaining prominence in the field, he said.The study revealed some surprising trends. As the corrected insulin response increased, there was a noticeable worsening in waist circumference, HDL (good cholesterol) levels, inflammation, and insulin resistance, if one did not consider accompanying factors. However, these seemingly negative trends were accompanied by better beta-cell function. Beta cells produce insulin, and their ability to do so is closely associated with diabetes risk \u2013 the better the beta cell function, the lower the risk.\u201cOur findings do not support the carbohydrate-insulin model of obesity,\u201d said Dr. Retnakaran. \u201cWe observed that a robust post-challenge insulin secretory response\u2014once adjusted for glucose levels\u2014is only associated with the beneficial metabolic effects\u201d.\u201cNot only does a robust post-challenge insulin secretory response not indicate adverse cardiometabolic health, but rather it predicts favorable metabolic function in the years to come.\u201dIn the long run, higher corrected insulin response levels were linked with better beta-cell function and lower glucose levels, without correlating with BMI, waist size, lipids, inflammation, or insulin sensitivity or resistance. Most importantly, women who had the highest CIR had a significantly reduced risk of developing pre-diabetes or diabetes in the future.\u201cThis research challenges the notion that high post-meal insulin levels are inherently bad and is an important step forward in our understanding of the complex roles insulin plays in regulation of metabolism,\u201d said Anne-Claude Gingras, Director of LTRI and Vice-President of Research at Sinai Health.Dr. Retnakaran hopes their findings will reshape how medical professionals and the public view insulin\u2019s role in metabolism and weight management.\u201cThere are practitioners who subscribe to this notion of higher insulin levels being a bad thing, and sometimes are making recommendations to patients to limit their insulin fluctuations after the meal. But it\u2019s not that simple,\u201d he said.Reference: \u201cFuture cardiometabolic implications of insulin hypersecretion in response to oral glucose: a prospective cohort study\u201d by Ravi Retnakaran, Jiajie Pu, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer and Bernard Zinman, 13 December 2023, eClinicalMedicine.DOI: 10.1016\/j.eclinm.2023.102363The study was funded by the Canadian Institutes of Health Research.\r\n","publisher":{"@id":"#Publisher","@type":"Organization","name":"DAILYZ HEALTH NEWS","logo":{"@type":"ImageObject","url":"http:\/\/dailyzhealthpress.com\/wp-content\/uploads\/2020\/12\/DAILYZ-HEALTH-NEWS-e1607165565708.png"}},"sourceOrganization":{"@id":"#Publisher"},"copyrightHolder":{"@id":"#Publisher"},"mainEntityOfPage":{"@type":"WebPage","@id":"https:\/\/dailyzhealthpress.com\/new-research-indicates-that-insulin-spike-after-eating-is-actually-a-good-thing\/","breadcrumb":{"@id":"#Breadcrumb"}},"author":{"@type":"Person","name":"Evan Vega","url":"https:\/\/dailyzhealthpress.com\/author\/evan-vega\/"},"image":{"@type":"ImageObject","url":"https:\/\/dailyzhealthpress.com\/wp-content\/uploads\/2024\/01\/Blood-Sugar-Diabetes-Meal.jpg","width":2000,"height":1333}}

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