The outbreak has been linked to the Andes virus, a type of hantavirus, officials said. The World Health Organization was first notified on May 2, 2026, of a cluster of severe acute respiratory illness among passengers and crew aboard the M/V Hondius cruise ship. WHO confirmed on May 6 that the virus involved was Andes virus and reported eight cases, including three deaths, as of May 8, according to CDC and WHO records. The CDC described the event as a multi-country hantavirus cluster involving international partners.

“WHO confirmed on May 6 that the virus involved was Andes virus and reported eight cases, including three deaths, as of May 8, according to CDC and WHO records.”

CDC officials emphasized that there is no evidence of broad spread in the United States at this time. Dr. Jay Bhattacharya, a CDC spokesperson, said there are currently no hantavirus cases reported in the U.S. The agency framed its response as precautionary monitoring of exposed travelers rather than evidence of domestic transmission. “The risk to the general public remains extremely low,” CDC officials said.

The CDC activated its emergency response in Atlanta immediately after the outbreak was reported. More than 100 CDC staff have been involved in the response, according to agency and media reports. On May 7, a CDC team was deployed to the Canary Islands to assist on site, where they interviewed each U.S. citizen about their potential exposure, officials said. The agency has coordinated with federal, state, local, and international health partners throughout the response.

American passengers who may have been exposed are being closely monitored. The CDC and its partners are tracking travelers for the virus’s incubation period, which can extend up to 42 days. Repatriated Americans were sent to a specialized medical facility in Nebraska for observation, officials confirmed. Monitoring also includes individuals potentially exposed on an aircraft by an infected cruise ship passenger. Reports indicate that 41 people across 16 states are currently under observation for possible exposure.

Prior to the repatriation of American citizens, the CDC issued a Health Alert Network advisory and posted a suite of resources on its website, including a toolkit, frequently asked questions, a situation overview, and a fact sheet. The agency has warned clinicians to be aware of possible imported cases and has alerted public health agencies, laboratories, and healthcare professionals nationwide as a precaution, according to CDC communications. Officials stressed that these measures are precautionary despite the low risk to the public.

The outbreak has resulted in multiple fatalities. The CDC’s Health Alert Network initially reported two deaths and one critically ill passenger at the time of notification. WHO’s subsequent update on May 8 confirmed eight total cases, including three deaths. Laboratory testing confirmed the presence of hantavirus in the cluster, specifically identifying the Andes virus as the cause.

Hantavirus disease has been monitored in the United States since 1993. According to CDC surveillance data, 890 cases had been reported nationwide as of the end of 2023. Of these, 859 were hantavirus pulmonary syndrome cases, while 31 involved non-pulmonary hantavirus infections. The CDC continues to track these cases through its ongoing surveillance program.

Rodríguez joined the CDC’s Vessel Sanitation Program in 2010 and was appointed chief in 2023, according to an internal CDC announcement obtained by STAT News. The program is responsible for overseeing public health standards on cruise ships under U.S. jurisdiction, focusing on preventing outbreaks of diseases such as norovirus and hantavirus. His retirement was announced internally on Wednesday, May 7, 2026, and confirmed by Benzinga, which cited the same CDC internal communication.

The Vessel Sanitation Program underwent significant staffing reductions in April 2025 as part of a restructuring led by U.S. Health Secretary Robert F. Kennedy Jr., according to CruiseHive.

Rodríguez’s departure coincides with a hantavirus outbreak on the Dutch cruise ship MV Hondius, which is not under U.S. jurisdiction and therefore not subject to CDC Vessel Sanitation Program inspections, according to Futurism. The outbreak has caused several deaths and raised concerns as U.S. passengers exposed on the ship have returned home, prompting a coordinated government response. The CDC stated on May 7 that it is “closely monitoring the situation” and considers the public health risk to Americans “extremely low,” according to STAT News. The U.S. State Department is coordinating efforts for affected passengers, the CDC said.

These layoffs eliminated all full-time CDC employees within the program, including the lead epidemiologist responsible for outbreak investigations, sources cited by Futurism confirmed. Post-layoffs, only 12 U.S. Public Health Service officers remained to conduct inspections and maintain program operations, CBS News reported and Futurism cited. Despite these reductions, a CDC spokesperson told People magazine that the program “remains fully staffed, including epidemiologists,” and continues to carry out all core activities.

Since the layoffs, the Vessel Sanitation Program has increased the number of cruise ship inspections compared to pre-2025 levels, CruiseHive reported. The program also adjusted health guidelines to address risks such as Legionnaires’ disease, enforcing stricter water testing and documentation requirements on ships including Royal Caribbean’s Symphony of the Seas and Norwegian Encore. CruiseHive’s analysis noted a downward trend in gastrointestinal outbreaks aboard cruise ships compared to 2025, a year marked by record norovirus cases during the period of staffing cuts.

The timing of Rodríguez’s retirement, exactly one year after the April 2025 layoffs, comes amid heightened scrutiny of the program’s capacity to respond to emerging public health threats on cruise ships. The MV Hondius hantavirus outbreak has drawn attention to vulnerabilities in global cruise ship health oversight, even as the CDC’s Vessel Sanitation Program maintains jurisdiction only over U.S.-flagged vessels and those docking at U.S. ports, according to Futurism.

When questioned by STAT News about Rodríguez’s replacement, the CDC did not provide a response. Officials have emphasized that the Vessel Sanitation Program continues to enforce rigorous public health standards despite previous staffing reductions. The program’s ongoing efforts include monitoring and responding to outbreaks, updating health protocols, and conducting inspections to safeguard passengers on cruise ships operating under U.S. jurisdiction.

The 2025 layoffs were part of broader federal spending cuts affecting multiple agencies, including the CDC, with some reductions linked to budgetary decisions influenced by Elon Musk’s involvement in federal spending priorities, according to Futurism. The 12 remaining U.S. Public Health Service officers have been credited by multiple sources with sustaining the program’s core functions during this period.

As the CDC monitors the situation on the MV Hondius and coordinates with other agencies, the Vessel Sanitation Program continues to adapt its practices to emerging health threats on cruise ships. The program’s history of managing outbreaks like norovirus and Legionnaires’ disease remains a critical component of public health efforts related to maritime travel under U.S. jurisdiction.