Metabolic | DAILYZ HEALTH NEWS

New Research Suggests That Cutting Exposure to Common Chemicals Could Slow Aging

Evan Vega — Sun, 14 Apr 2024 15:28:27 +0000

Researchers at Nagoya University have linked aldehydes, byproducts from alcohol, pollution, and smoke, to premature aging and DNA damage, proposing potential strategies to mitigate aging effects and highlighting the impact of environmental factors on health.

Researchers at Nagoya University in Japan have discovered that aldehydes are metabolic byproducts associated with premature aging. Published in Nature Cell Biology, their findings reveal insights into premature aging diseases and potential strategies to combat aging in healthy individuals such as controlling exposure to aldehyde-inducing substances including alcohol, pollution, and smoke.

A person’s health can be harmed by aldehydes. However, the group’s findings suggest these detrimental effects also include aging. The team who made this discovery included Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, and Tomoo Ogi of Histones are crosslinked with DNA (histone-DPC) following formaldehyde exposure, leading to the malfunction of cellular processes such as transcription. Credit: Reiko Matsushita

Aldehydes are harmful because they are highly reactive with DNA and proteins. In the body, they form DNA-protein crosslinks (DPCs) that block important enzymes in typical cell proliferation and maintenance processes, causing these processes to malfunction and the patient to age.

Focusing on DPCs caused by aldehyde, the scientists used a method called DPC-seq to investigate the link between aldehyde accumulation and DNA damage in premature-aging disease patients. In a series of experiments, the researchers discovered that the TCR complex, VCP/p97, and the proteasome are involved in the removal of formaldehyde-induced DPCs in actively transcribed regions. This was confirmed by a mouse model lacking both aldehyde clearance processes and the TCR pathway that showed worse AMeD syndrome symptoms.

These processes are important because they are related to the clearance of aldehydes. It suggests an association between premature aging diseases and aldehyde accumulation.

Research Findings and Future Directions

Professor Ogi is hopeful about the implications of their findings, stating: “By elucidating the mechanism by which DNA damage heals quickly, we have revealed part of the cause of genetic premature aging.”

“Our research opens up new avenues for understanding the underlying mechanisms of premature aging diseases and offers potential targets for therapeutic intervention,” Oka said. “By elucidating the role of aldehydes in DNA damage and aging, we are paving the way for future studies aimed at developing novel treatments and interventions.”

He continued: “The development of therapeutic drugs has not progressed because we have not fully understood the causes of AMeD syndrome and Cockayne syndrome. This study suggests that the patient’s pathological condition is related to DPC derived from aldehydes generated within cells. These results are expected to help in the search for compounds that remove aldehydes, thus aiding in the formulation of therapeutic drug candidates.”

This research has implications that extend beyond genetic diseases, as their findings suggest that aldehyde-induced DNA damage may play a role in the aging process in healthy individuals too. By pinpointing aldehydes as substances that contribute to aging, this study sheds light on the intricate connection between environmental factors and cellular aging. This may have significant implications for human health and lifespan.

Reference: “Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair” by Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada and Tomoo Ogi, 10 April 2024, Nature Cell Biology.
DOI: 10.1038/s41556-024-01401-2

The post New Research Suggests That Cutting Exposure to Common Chemicals Could Slow Aging first appeared on DAILYZ HEALTH NEWS.

New Research Indicates That Popular Diabetes Drug Could Impact Brain Development During Pregnancy

Evan Vega — Sun, 31 Mar 2024 20:58:36 +0000

Research indicates that metformin, while beneficial for pregnant animals, might not positively affect their offspring, underscoring the complexity of managing gestational diabetes risks and the importance of pursuing preventive strategies.

As cases of gestational diabetes and metabolic disorders increase during pregnancy, the prescription of metformin has become more common. Despite understanding that this oral antidiabetic medication can pass through the placental barrier, its effects on a child’s brain development remain largely unclear. However, a cross-disciplinary team from the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) has recently shown in a mouse study that while metformin benefits pregnant animals, these positive effects do not extend to their offspring.

The results were published in the specialist journal Molecular Metabolism.

Current figures show that around one in six pregnant women worldwide are affected by a special form of diabetes known as gestational diabetes. According to the Robert Koch Institute, 63,000 women in Germany were affected by the disease in 2021, and the trend is increasing.
These numbers are alarming because excessively high blood sugar levels during pregnancy are associated with negative consequences for mother and child. This increases the risk of affected women developing type 2 diabetes later on and their children have a higher risk of developing metabolic disorders and being overweight.

Long-Term Effect of Metformin on Offspring is Unclear

For several years, the placenta-crossing oral antidiabetic agent metformin has been increasingly gaining importance as an alternative to New Research Indicates That Popular Diabetes Drug Could Impact Brain Development During Pregnancy first appeared on DAILYZ HEALTH NEWS.

Tardigrade Proteins Slow Aging in Human Cells

Evan Vega — Sat, 30 Mar 2024 22:56:11 +0000

Researchers have discovered that proteins from tardigrades, known for surviving extreme conditions, can slow molecular processes in human cells, offering promising applications in aging research and cell storage. This finding paves the way for developing new technologies to enhance human health and treat diseases.

Researchers at the University of Wyoming have advanced our understanding of how tardigrades survive extreme conditions and shown that proteins from the microscopic creatures expressed in human cells can slow down molecular processes.

This makes the tardigrade proteins potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.

The new study, published in the journal Protein Science, examines the mechanisms used by tardigrades to enter and exit from suspended animation when faced by environmental stress. Led by Senior Research Scientist Silvia Sanchez-Martinez in the lab of UW Department of Molecular Biology Assistant Professor Thomas Boothby, the research provides additional evidence that tardigrade proteins eventually could be used to make life-saving treatments available to people where refrigeration is not possible — and enhance storage of cell-based therapies, such as stem cells.

Measuring less than half a millimeter long, tardigrades — also known as water bears — can survive being completely dried out; being frozen to just above University of Wyoming Senior Research Scientist Silvia Sanchez-Martinez, left, and Department of Molecular Biology Assistant Professor Thomas Boothby led new research providing additional evidence that tardigrade proteins eventually could be used to make life-saving treatments available to people where refrigeration is not possible. Credit: Vindya Kumara

Research Findings and Future Directions

They survive by entering a state of suspended animation called biostasis, using proteins that form gels inside of cells and slow down life processes, according to the new UW-led research. Co-authors of the study are from institutions including the

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>NASA Astrobiology Institute, and the U.S. National Science Foundation.

The post Tardigrade Proteins Slow Aging in Human Cells first appeared on DAILYZ HEALTH NEWS.

Natural Ingredient Found in Coffee Could Keep Your Muscles Young

Evan Vega — Sun, 24 Mar 2024 01:40:26 +0000

By National University of Singapore, Yong Loo Lin School of Medicine March 23, 2024

A groundbreaking study found that trigonelline, found in coffee and fenugreek, boosts muscle health in aging by improving NAD+ levels and mitochondrial function, offering new strategies for healthy aging and disease prevention.

A research consortium led by Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function.

In an international collaboration among the University of Southampton, University of Melbourne, University of Tehran, University of South Alabama, University of Toyama, and University of Copenhagen, the work builds on a previous collaborative study that described novel mechanisms of human sarcopenia.

Sarcopenia is a condition where cellular changes that happen during aging gradually weaken the muscles in the body and lead to accelerated loss of muscle mass, strength and reduced physical independence.

One important problem during sarcopenia is that the cellular cofactor NAD+ declines during aging, while mitochondria, the energy powerhouses in our cells, produce less energy. The study team discovered that levels of trigonelline were lower in older people with sarcopenia. Providing this molecule in pre-clinical models resulted in increased levels of NAD+, increased mitochondrial activity, and contributed to the maintenance of muscle function during aging.

Nutritional Approaches to Combat Aging

NAD+ levels can be enhanced with different dietary precursors like the essential amino Natural Ingredient Found in Coffee Could Keep Your Muscles Young first appeared on DAILYZ HEALTH NEWS.

How Your High-Protein Diet Could Be Hardening Your Arteries

Evan Vega — Tue, 27 Feb 2024 08:36:40 +0000

High protein consumption may elevate atherosclerosis risk by activating immune cells that contribute to arterial plaque formation, with leucine playing a critical role, according to a study by the University of Pittsburgh School of Medicine.

High protein consumption may elevate atherosclerosis risk by activating immune cells that contribute to arterial plaque formation, with leucine playing a critical role.

University of Pittsburgh School of Medicine researchers discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk. The findings were published on February 19 in Nature Metabolism.

The study, which combined small human trials with experiments in mice and cells in a Petri dish, showed that consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation, driving the disease risk. Furthermore, the scientists showed that one amino Babak Razani, M.D., Ph.D. Credit: University of Pittsburgh

According to a survey of the average American diet over the last decade, Americans generally consume a lot of protein, mostly from animal sources. Further, nearly a quarter of the population receives over 22% of all daily calories from protein alone.

That trend is likely driven by the popular idea that dietary protein is essential to healthy living, says Razani. But his and other groups have shown that overreliance on protein may not be such a good thing for long-term health.

Mechanisms and Implications for Human Health

Following their 2020 research, in which Razani’s laboratory first showed that excess dietary protein increases atherosclerosis risk in mice, his next study in collaboration with Bettina Mittendorfer, Ph.D., a metabolism expert at the University of Missouri, Columbia, delved deeper into the potential mechanism and its relevance to the human body.

To arrive at the answer, Razani’s laboratory, led by first-authors Xiangyu Zhang, Ph.D., and Divya Kapoor, M.D., teamed up with Mittendorfer’s group to combine their expertise in cellular biology and metabolism and perform a series of experiments across various models – from cells to mice to humans.

“We have shown in our mechanistic studies that

Amino acids are a set of organic compounds used to build proteins. There are about 500 naturally occurring known amino acids, though only 20 appear in the genetic code. Proteins consist of one or more chains of amino acids called polypeptides. The sequence of the amino acid chain causes the polypeptide to fold into a shape that is biologically active. The amino acid sequences of proteins are encoded in the genes. Nine proteinogenic amino acids are called "essential" for humans because they cannot be produced from other compounds by the human body and so must be taken in as food.

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>amino acids, which are really the building blocks of the protein, can trigger disease through specific signaling mechanisms and then also alter the metabolism of these cells,” Mittendorfer said. “For instance, small immune cells in the vasculature called macrophages can trigger the development of atherosclerosis.”

Based on initial experiments in healthy human subjects to determine the timeline of immune cell activation following ingestion of protein-enriched meals, the researchers simulated similar conditions in mice and in human macrophages, immune cells that are shown to be particularly sensitive to amino acids derived from protein.

Their work showed that consuming more than 22% of daily dietary calories through protein can negatively affect macrophages that are responsible for clearing out cellular debris, leading to the accumulation of a “graveyard” of those cells inside the vessel walls and worsening of atherosclerotic plaques over time. Interestingly, the analysis of circulating amino acids showed that leucine – an amino acid enriched in animal-derived foods like beef, eggs, and milk – is primarily responsible for abnormal macrophage activation and atherosclerosis risk, suggesting a potential avenue for further research on personalized diet modification, or “precision nutrition.”

Navigating Protein Consumption and Cardiovascular Health

Razani is careful to note that many questions remain to be answered, mainly: What happens when a person consumes between 15% of daily calories from protein as recommended by the USDA and 22% of daily calories from protein, and if there is a ‘sweet spot’ for maximizing the benefits of protein – such as muscle gain – while avoiding kick-starting a molecular cascade of damaging events leading to How Your High-Protein Diet Could Be Hardening Your Arteries first appeared on DAILYZ HEALTH NEWS.

Unlocking Your Body’s Natural Weight Loss System That Works Like Wegovy, Ozempic and Mounjaro

Evan Vega — Wed, 21 Feb 2024 20:18:03 +0000

Incretin hormones, produced in our gut, play a pivotal role in managing metabolism and weight, akin to the function of drugs like Wegovy, Ozempic, and Mounjaro. This natural weight loss system, activated by our dietary choices and the health of our gut microbiome, offers a built-in method for obesity and diabetes control. By focusing on nurturing our gut health through proper nutrition, we can unlock this natural mechanism, offering a sustainable approach to weight management that parallels the benefits of these modern medications.

Recent drugs like Wegovy, Ozempic, and Mounjaro represent breakthroughs in metabolic disease treatment, offering new hope for managing obesity and diabetes. However, their use raises questions about long-term effects and suitability for certain groups, underscoring the importance of a healthy lifestyle.

Wegovy, Ozempic, and Mounjaro are weight loss and diabetes drugs that have made quite a splash in health news. They target regulatory pathways involved in both obesity and diabetes and are widely considered breakthroughs for weight loss and blood sugar control.

But do these drugs point toward a root cause of metabolic disease? What inspired their development in the first place?

It turns out your body produces natural versions of these drugs – also known as incretin hormones – in your gut. It may not be surprising that nutrients in food help regulate these hormones. But it may intrigue you to know that the trillions of microbes in your gut are key for orchestrating this process.

I am a gastroenterologist at the GLP-1 serves many functions in the body. Credit: Lthoms11/Wikimedia Commons, CC BY-SA

Prior to modern processed foods, metabolic regulatory pathways were under the direction of a diverse healthy gut microbiome that used these hormones to naturally regulate your metabolism and appetite. However, food processing, aimed at improving shelf stability and enhancing taste, removes the bioactive molecules like fiber and polyphenols that help regulate this system.

Removal of these key food components and the resulting decrease in gut microbiome diversity may be an important factor contributing to the rise in obesity and diabetes.

A Short Track to Metabolic Health

Wegovy and Ozempic reinvigorate the colonic brake downstream of food and microbes with molecules similar to GLP-1. Researchers have demonstrated their effectiveness at weight loss and blood sugar control.

Mounjaro has gone a step further and combined GLP-1 with a second hormone analog derived from the upper gut called GIP, and studies are showing this combination therapy to be even more effective at promoting weight loss than GLP-1-only therapies like Wegovy and Ozempic.

These drugs complement other measures like gastric bypass surgery that are used in the most extreme cases of metabolic disease. These surgeries may in part work much like Wegovy and Ozempic by bypassing digestion in segments of the gastrointestinal tract and bathing your gut microbes in less digested food. This awakens the microbes to stimulate your gut cells to produce GLP-1 and PYY, effectively regulating appetite and metabolism.

Many patients have seen significant improvements to not only their weight and blood glucose but also reductions in important cardiovascular outcomes like strokes and heart attacks. Medical guidelines support the use of new incretin-based medications like Wegovy, Ozempic and Mounjaro to manage the interrelated metabolic conditions of diabetes, obesity and Unlocking Your Body’s Natural Weight Loss System That Works Like Wegovy, Ozempic and Mounjaro first appeared on DAILYZ HEALTH NEWS.

Scientists Develop Simple and Cost-Effective Early Diabetes Test

Evan Vega — Wed, 21 Feb 2024 09:17:13 +0000

Researchers have introduced an efficient diabetes detection method using a simple mathematical calculation from a blood test, proving its reliability and affordability in a study published in the Journal of Diabetes.

Diabetes frequently goes unnoticed until it has caused organ or nerve damage, partly because early-stage diagnosis is challenging and time-consuming.

An international team of researchers headed by Associate Professor Dr. Johannes Dietrich from the Department of Medicine I of Ruhr University Bochum at St. Josef Hospital in Bochum, Germany, has shown that a mathematical calculation based on just two values taken from a blood sample enables the reliable and inexpensive diagnosis of diabetes at an early stage. The researchers recently published their findings in the Journal of Diabetes.

Diabetes often remains long undetected

“Thirty percent of all people who suffer from diabetes haven’t yet been diagnosed and, consequently, don’t receive any treatment,” points out Johannes Dietrich. This is partly due to the fact that it’s not easy to detect the disease at an early stage. “Diabetes sets in gradually, and our diagnostic options are not sensitive enough to detect it; moreover, they aren’t specific enough, meaning that false positive results can also occur,” stresses Dietrich.

Together with his colleagues from Germany, India, Singapore, and the UK, he has researched a new method for the early detection of diabetes. The method, called SPINA Carb, is based on mathematical modeling. All that is required is a blood sample, which is taken in the morning before the patient’s have their breakfast.

Two values measured in the sample are relevant: the Scientists Develop Simple and Cost-Effective Early Diabetes Test first appeared on DAILYZ HEALTH NEWS.

New Discovery Could Improve the Efficiency of Diabetes Treatments

Evan Vega — Thu, 15 Feb 2024 21:04:34 +0000

Recent research has unveiled that the GDF15 protein may enhance diabetes treatment by reducing glucose synthesis and liver fibrosis, offering a new approach to managing type 2 diabetes and associated metabolic disorders.

New methods to decrease glucose production in the liver

A study led by the University of Barcelona and the Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM) uncovered a novel mechanism that could enhance the effectiveness of existing diabetes treatments. This study, which was performed using mice and cell cultures, has the potential to pave new paths for tackling metabolic diseases that represent a significant worldwide health issue.

The study, published in the journal Metabolism, focuses on the GDF15 protein, a factor that is expressed at high levels in many diseases, such as heart failure, cancer, and fatty liver disease. Obese patients also have elevated levels of this protein, but its function is altered and those affected may develop resistance to GDF15 — that is, a reduction in the effectiveness of its activity.

The study is led by Professor Manuel Vázquez-Carrera, from the Faculty of Pharmacy and Food Sciences of the UB, the Institute of Biomedicine of the UB (IBUB), the Sant Joan de Déu Research Institute (IRSJD) and CIBERDEM. The study also highlights the participation of researchers Patricia Rada and Ángela María Valverde, also collaborators at CIBERDEM, the Spanish National Research Council (CSIC), and the Autonomous University of Madrid (UAM). The work has the collaboration of Professor Walter Wahli of the University of Lausanne (Switzerland), among other experts.

New alternatives to reduce glucose synthesis in the liver

“Our study reveals that GDF15 inhibits glucose synthesis in the liver. This pathway plays a decisive role in the generation of hyperglycaemia (increased blood glucose levels) in patients with type 2 diabetes mellitus,” says Professor Manuel Vázquez-Carrera.

“The action of the protein would also help reduce the presence of liver fibrosis, a condition associated with increased mortality in patients with fatty liver disease,” the researcher notes.

The study reveals that mice deficient in GDF15 have glucose intolerance and low levels of AMPK protein in the liver, which is a sensor of energy metabolism in the cell against type 2 diabetes.

Moreover, increased glucose synthesis in the liver (hepatic gluconeogenesis) was also detected in these study models, as well as increased liver fibrosis.

All indications are that all the described alterations were triggered by increased hepatic levels of transforming growth factor-beta 1 (TGF-β1) and an SMAD3mediator protein, which are the main inducers of liver fibrosis. Thus, treatment with recombinant CDF15 can activate AMPK and decrease levels of active SMAD3 in mouse liver and in primary hepatocyte cultures.

“In conclusion, the results indicate that GDF15 activates AMPK protein and inhibits hepatic gluconeogenesis and fibrosis through the reduction of the TGF-β1/SMAD3 pathway,” says Vázquez-Carrera.

“These results suggest that modulation of GDF15 levels could be useful to improve the effectiveness of current anti-diabetic treatments, as hepatic gluconeogenesis is key in hyperglycaemia in patients with type 2 diabetes mellitus, and serum TGF-β1 levels are also increased in these patients,” concludes the researcher.

Reference: “GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway” by Javier Jurado-Aguilar, Emma Barroso, Maribel Bernard, Meijian Zhang, Mona Peyman, Patricia Rada, Ángela M. Valverde, Walter Wahli, Xavier Palomer and Manuel Vázquez-Carrera, 3 January 2024, Metabolism.
DOI: 10.1016/j.metabol.2023.155772

The post New Discovery Could Improve the Efficiency of Diabetes Treatments first appeared on DAILYZ HEALTH NEWS.

Scientists Uncover the Hidden Role of Mitochondria in Dietary Fat Processing

Evan Vega — Wed, 07 Feb 2024 03:43:42 +0000

Pictures show small intestinal villi from wild type (top) and enterocyte-specific DARS2 knockout mice (bottom) stained for PLIN2 (yellow), TGN38 (red), E-cadherin (green) and DNA (DAPI, blue). Credit: Chrysanthi Moschandrea

Maintaining balanced lipid levels is essential for good health. Consuming too much fatty food can lead to metabolic disorders like obesity and atherosclerosis, but fats are also a vital part of our diet. When digested, lipids provide the body with crucial building blocks and aid in the absorption of vital vitamins.

In a new study published in the journal Nature, a team of researchers led by Professor Manolis Pasparakis and their collaborators Professor Aleksandra Trifunovic and Professor Christian Frezza at the Excellence Cluster CECAD of the University of Cologne, and Professor Jörg Heeren at the University of Hamburg, report on a new mechanism that regulates the processing and transport of dietary lipids by the intestine.

Mitochondrial Function in Enterocytes

The researchers studied the function of mitochondria – organelles acting as powerhouses of the cell – in enterocytes, cells that line the intestine and specialize in the absorption and transport of nutrients from digested food. They found that disruption of mitochondrial function in the intestines of mice caused abnormal accumulation of dietary fat in enterocytes and impaired delivery of lipids to the peripheral organs.

A key finding of the study was that, when mitochondria did not function properly, enterocytes showed impaired packaging and transport of lipids in the form of chylomicrons. Chylomicrons are crucial carriers of dietary fats, and their proper formation and transport are essential for the absorption of nutrients.

Implications of the Study

“This discovery marks a significant leap forward in understanding the crucial role of mitochondria in dietary lipid transport and metabolism,” said Dr Chrysanthi Moschandrea, the lead author of the study. The implications of this discovery go beyond the realm of basic research. “These findings provide new perspectives for the better understanding of the gastrointestinal symptoms in patients suffering from mitochondrial disease, and may also lead to new therapeutic approaches,” added Professor Aleksandra Trifunovic.

Reference: “Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes” by Chrysanthi Moschandrea, Vangelis Kondylis, Ioannis Evangelakos, Marija Herholz, Farina Schneider, Christina Schmidt, Ming Yang, Sandra Ehret, Markus Heine, Michelle Y. Jaeckstein, Karolina Szczepanowska, Robin Schwarzer, Linda Baumann, Theresa Bock, Efterpi Nikitopoulou, Susanne Brodesser, Marcus Krüger, Christian Frezza, Joerg Heeren, Aleksandra Trifunovic and Manolis Pasparakis, 20 December 2023, Nature.
DOI: 10.1038/s41586-023-06857-0

The post Scientists Uncover the Hidden Role of Mitochondria in Dietary Fat Processing first appeared on DAILYZ HEALTH NEWS.

Surprising Link Discovered Between Body Temperature and Depression

Evan Vega — Tue, 06 Feb 2024 16:43:12 +0000

A UC San Francisco study shows a correlation between depression and higher body temperatures, hinting at new treatment methods through temperature regulation. With data from over 20,000 global participants, this research suggests that heat-based treatments could offer benefits for those with depression. Credit: SciTechDaily.com

New study may support heat-based treatment to stimulate self-cooling as new treatment.

People with depression have higher body temperatures, suggesting there could be a mental health benefit to lowering the temperatures of those with the disorder, a new UC San Francisco-led study found.

The study, published on February 5 in This effort was funded under MTEC solicitation MTEC-20-12-Diagnostics-023 and the USAMRDC under the Department of Defense (DOD). The #StartSmall foundation (#7029991) and Oura Health Oy (#134650) also provided funding for this work. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government.

The post Surprising Link Discovered Between Body Temperature and Depression first appeared on DAILYZ HEALTH NEWS.