Younger adults admitted for peripheral vascular disease with cardiovascular comorbidities

In recent years, hospital admissions for peripheral vascular disease (PVD) with cardiovascular disease (CVD) and serious adverse cardiac and cerebrovascular events (MACCE) have occurred at a younger age than in previous years, according to those presented at American Heart Study Results Association (AHA) Scientific Sessions 2021 from November 13-15, 2021.

The study included two nationwide cohorts of young adults aged 18 to 44 who were hospitalized for PVD: a cohort from 2007 (n = 37,099) and a cohort from 2017 (n = 46,760). MACCE and mean age at presentation with CVD risk factors were identified, with age at admission being given as mean ± standard deviation. A student’s t-test was used to compare admission age between the two cohorts.

Between 2007 and 2017, total registrations rose from 0.4% to 0.5%. Non-selective PVD images occurred in 2017 in significantly younger people than in 2007 (mean 35 ± 7 vs. 38 ± 6 years; P <0.001). Comorbid risk factors included smoking, high blood pressure, obesity, diabetes mellitus, and congestive heart failure, which occurred in 2007 with a mean age of 39 ± 5 years. The mean age for smoking decreased to 36 ± 6 years (P <0.001), 38 ± 6 years for hypertension and diabetes (P <0.001), and 37 ± 6 years for congestive heart failure and obesity (P <0.001) in 2017. In 2007, the mean age for MACCE with PVD was 39 ± 5 years; this decreased to 36 ± 7 years in the 2017 cohort (P <0.001). Other declines in mean age at presentation included cardiogenic shock (P = 0.004), acute myocardial infarction (P <0.001), PCI procedures (P <0.001), ventricular tachyarrhythmias (P <0.001), and stroke (P <.001).

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As the researchers found, the study shows “increasing trends in PVD hospital admissions at a significantly younger age with associated cardiovascular comorbidities and MACCE in recent years. The relationship between young age and complicated / severe PVD recordings with frequent comorbidities should be further investigated. “


R. Desai, S. Shanker, A. Nepal et al. Hospital admissions for peripheral vascular disease with the risk of cardiovascular disease and serious adverse cardiac and cerebrovascular events occur at an increasingly younger age in two national cohorts 10 years apart. Presented at: AHA Scientific Sessions 2021; 13-15 November 2021. Poster P2969.

This article originally appeared on The Cardiology Advisor

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