Infectious Disease

US woman is third person to achieve sustained HIV remission after stem cell transplant

February 15, 2022

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Bryson Y, et al. LB 65. Presented at: Conference on Retroviruses and Opportunistic Infections; Feb. 12-16, 2022 (virtual meeting).

Disclosures:
The authors reports no relevant financial disclosures.

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A woman from the United States is the third person to achieve sustained treatment-free HIV remission after undergoing a stem cell transplant, researchers announced.

The unnamed woman developed high-risk acute myeloid leukemia (AML) while on ART in 2017, 4 years after being diagnosed with HIV, the researchers reported Tuesday at the Conference on Retroviruses and Opportunistic Infections.

Bryson Y, et al.  LB 65. Presented at: Conference on Retroviruses and Opportunistic Infections;  Feb. 12-16, 2022 (virtual meeting).

Bryson Y, et al. LB 65. Presented at: Conference on Retroviruses and Opportunistic Infections; Feb. 12-16, 2022 (virtual meeting).

She received a haplo-cord stem cell transplant from a donor with the rare CCR5-delta 32 genetic mutation — which creates natural resistance by preventing HIV from entering human cells — and achieved AML remission.

She ceased ART 37 months post-transplant and has remained in HIV remission for at least 14 months, the researchers reported.

The first two patients who achieved sustained treatment-free HIV remission after receiving stem cells with the CCR5-delta 32 mutation were known as the “Berlin patient” — later identified as Timothy Ray Brown, who died in 2020 following a recurrence of leukemia — and the “London patient,” who identified himself as Adam Castillejo and was last reported to be in HIV remission for 30 months in 2020.

[Editor’s note: This story will be updated with more details.]

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Conference on Retroviruses and Opportunistic Infections (CROI)

Conference on Retroviruses and Opportunistic Infections (CROI)

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