Infectious Disease
US woman is third person to achieve sustained HIV remission after stem cell transplant
February 15, 2022
1 min read
Source/Disclosures
Published by:
sources:
Bryson Y, et al. LB 65. Presented at: Conference on Retroviruses and Opportunistic Infections; Feb. 12-16, 2022 (virtual meeting).
Disclosures:
The authors reports no relevant financial disclosures.
ADD TOPIC TO EMAIL ALERTS
Receive an email when new articles are posted on
Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe
We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected].
Back to Healio
A woman from the United States is the third person to achieve sustained treatment-free HIV remission after undergoing a stem cell transplant, researchers announced.
The unnamed woman developed high-risk acute myeloid leukemia (AML) while on ART in 2017, 4 years after being diagnosed with HIV, the researchers reported Tuesday at the Conference on Retroviruses and Opportunistic Infections.
Bryson Y, et al. LB 65. Presented at: Conference on Retroviruses and Opportunistic Infections; Feb. 12-16, 2022 (virtual meeting).
She received a haplo-cord stem cell transplant from a donor with the rare CCR5-delta 32 genetic mutation — which creates natural resistance by preventing HIV from entering human cells — and achieved AML remission.
She ceased ART 37 months post-transplant and has remained in HIV remission for at least 14 months, the researchers reported.
The first two patients who achieved sustained treatment-free HIV remission after receiving stem cells with the CCR5-delta 32 mutation were known as the “Berlin patient” — later identified as Timothy Ray Brown, who died in 2020 following a recurrence of leukemia — and the “London patient,” who identified himself as Adam Castillejo and was last reported to be in HIV remission for 30 months in 2020.
[Editor’s note: This story will be updated with more details.]
ADD TOPIC TO EMAIL ALERTS
Receive an email when new articles are posted on
Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe
We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected].
Back to Healio