A systematic understanding of the burden of neurological disorders at the sub-national level is not readily available for India. This study presents a comprehensive analysis of the disease burden and trends in neurological disorders at the state level in India.
With an aging global population, the burden of neurological diseases is increasing rapidly and posing a challenge to the sustainability of health systems, including in low and middle income countries. Also in India, due to the rapid demographic and epidemiological change in the country, the burden of neurological diseases is expected to increase.
Evidence on the incidence, prevalence and burden of disease associated with neurological disorders in India is scarce. Few local studies have reported disease burden for some neurological disorders. We previously reported the distribution of stroke and cancer of the brain and nervous system at the federal level. However, an up-to-date and comprehensive understanding of the extent and trends of all neurological disorders is not available, which is necessary for evidence-based prevention strategies, health planning, priority setting and resource allocation.
In 2020, the 73rd World Health Assembly, on global action on epilepsy and other neurological diseases, called for a globally integrated strategy, underpinned by preventive, diagnostic, therapeutic and rehabilitation plans, to more effectively address neurological diseases in low and middle income countries.
Using all available data from multiple sources, we estimated the prevalence or incidence and Disability Adjusted Life Years (DALYs) for neurological disorders from 1990 to 2019 for all states of India as part of the Global Burden of Diseases, Injuries and Risk Factors. 2019 study. We assessed the contribution of each neurological disorder to deaths and DALYs in India in 2019, their trends in prevalence or incidence and DALY rates over time, and heterogeneity between states of India. We also assessed the Pearson correlation coefficient between the state sociodemographic index (SDI) and the prevalence or incidence and DALY rates of each neurological disorder. In addition, we assessed the contribution of known risk factors to DALYs from neurological diseases. We calculated 95% uncertainty intervals (UIs) for the mean estimates.
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The Global Burden of Disease study provides the most comprehensive global health estimates and examines global, national and regional trends for mortality and morbidity from major illnesses, injuries and risk factors to understand the health challenges of the 21st century.
