Infectious Disease

Study finds no pattern of MIS-A after COVID-19 vaccination

December 07, 2021

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Disclosure:
Belay reports that he has received grants for Pfizer COVID-9 vaccine studies. Please refer to the study for all relevant financial information from the other authors.

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According to a study published in Clinical Infectious Diseases, researchers found no pattern of multisystem inflammatory syndrome in adults after receiving a COVID-19 vaccination without prior SARS-CoV-2 infection.

SARS-CoV-2 infection can cause multisystem inflammatory syndrome (MIS-A) in adults and a similarly severe illness in children, MIS-C, days or weeks after the illness, causing symptoms in different parts of the body.

Source: Adobe Stock.

There was no general pattern of multisystem inflammatory syndrome in adults following COVID-19 vaccination without prior SARS-CoV-2 infection. Source: Adobe Stock.

Ermias D. Belay

In the new study Ermias D. Belay MD, a member of the CDC’s COVID-19 Response Team, and colleagues stated that “MIS-A has been added to the list of adverse events to be monitored as part of the emergency permits issued for COVID-19 vaccines.”

“The study was initiated to follow up cases of people suspected of having multisystem inflammatory syndrome in adults after the COVID-19 vaccine became available to learn more about and test for MIS-A and determine if the COVID -19 vaccination affects MIS-A. ”A CDC spokesman told Healio.

For the study, Belay and colleagues evaluated reports from patients with MIS-A that the CDC received after COVID-19 vaccines became available between December 14, 2020 and April 30, 2021.

The assessment revealed 20 patients who met the case definition for MIS-A, including 16 (80%) who had a median previous COVID-19-like illness averaging 26 days prior to the start of MIS-A. All 20 patients had laboratory evidence of SARS-CoV-2 infection.

Of the 20 patients, seven (35%) had received a median COVID-19 vaccine 10 days before the onset of MIS-A, and three had a second dose of COVID-19 vaccine 4, 17 and 22 days before MIS-A receive. A beginning.

“Although seven patients were reported to have received a COVID-19 vaccine, all had evidence of previous SARS-CoV-2 infection,” wrote Belay and colleagues. “Given the widespread use of COVID-19 vaccines, the lack of a MIS-A report associated with vaccination alone with no evidence of an underlying SARS-CoV-2 infection is reassuring.”

The CDC spokesman told Healio that “clinics and health department officials should be familiar with the MIS-A case definition and ensure that suspected cases are reported,” as the disease is severe and difficult to detect.

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