Sleep problems and intercranial stress within the aged with Alzheimer’s illness

According to the study results published in Alzheimer & Dementia, there may be a correlation between T2 / T1 in night behavior in older people with Alzheimer’s disease (AD).

Since sleep disorders have been found to have a strong correlation with AD leads, early diagnosis and interventions could improve the quality of life for this population. The researchers in the study wanted to investigate whether the intracranial pressure of older patients with AD and sleep disorders changes compared to patients with only AD.

The researchers used data from the Ambulatory of Cognitive Behavioral Neurology (ANEC) at the Universidade Federal de São Carlos in Brazil. The study cohort consisted predominantly of women. The most common clinical dementia rating was 3 in patients with AD, indicating more advanced dementia.

The full group showed a correlation between T2 / T1 (P = 0.01 / ρ = -0.42), which was verified as dimensions that rated awakening and / or ascent during the night (P = 0.04 / ρ = -0.36).

There were no correlations between intracranial pressure ratings and other study variables. However, the results were different when the patients were divided into groups with and without sleep disorders compared to the general assessment.

This study was limited by the limited sample size because a larger sample size may have produced different results.

“Although no difference was found between patients with AD and TS when assessing ICP morphology, there was a difference between the groups with AD and without AD. Similar studies should consider expansion and assessment in different contexts, ”concluded the study researchers.


Ribeiro EB, Ramos CF, Vale FAC, Frigieri G. Clinical evaluation of sleep disorders in the elderly with Alzheimer’s disease and its relationship to intracranial pressure using a non-invasive method. Alzheimer’s & dementia. Published online on December 7, 2020. doi: 10.1002 / alz.043625


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