Infectious Disease

Severe COVID-19 significantly increases the risk of death within 12 months of diagnosis

December 22, 2021

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Data showed that patients with severe COVID-19 were more than twice as likely to have mortality within 12 months of diagnosis as those with mild or moderate disease or without infection.

According to researchers, the increased risk of death was particularly high in people under 65 years of age.

Reference: Mainous AG, et al. Front Med. 2021; doi: 10.3389 / fmed.2021.778434.

“Post-acute consequences of COVID-19 are not well understood” Arch G. Mainous III, PhD, Professor in the Department of Health Research, Management, and Policy at the University of Florida, and colleagues wrote in Frontiers in Medicine.

Therefore, they analyzed the electronic health records of 13,638 patients (64.5% <65 years; 41.6% men; 63.8% white) within a health system and followed them up for 12 months after the results of a COVID-19 polymerase test Chain reaction tests were recorded. Across the cohort, 178 patients had severe COVID-19 and were hospitalized for some reason during the first 30 days of their follow-up, 246 had mild or moderate COVID-19, and 13,214 had tested negative for SARS-CoV-2. A total of 2,686 patients died in the follow-up period.

According to Mainous and colleagues, the adjusted all-cause mortality risk at 12 months was significantly higher in patients with severe COVID-19 compared to people without the disease (HR = 2.5; 95% CI, 2.02-3.09) and patients with mild or moderate COVID-19 (HR = 1.87; 95% CI 1.28-2.74). The researchers wrote that “the vast majority of deaths – 79.5% – had causes other than respiratory or cardiovascular disease”.

Patients under 65 years of age who had severe COVID-19 were more than three times the risk of death at 12 months compared to those who did not have COVID-19 (HR = 3.33; 95% CI, 2.35-4 , 73) and more than twice the risk compared to patients with mild or moderate COVID-19 (HR = 2.83; 95% CI 1.59-5.04). Patients 65 years of age and older with severe COVID-19 had an increased risk of mortality after 12 months compared to those who did not have the disease (HR = 2.17; 95% CI, 1.66-2.84), but not patients with mild or moderate COVID -19 (HR = 1.41; 95% CI, 0.84-2.34).

“These novel results identify critical areas for future research and demonstrate the ubiquitous nature of COVID-19 episodes,” wrote Mainous and colleagues. “They also suggest that people die from a variety of diseases.”

Arch G. Mainous III

In a press release, Mainous said the results also underscore the importance of “being even more vigilant in reducing severe COVID-19 episodes”.

“Taking your chances and hoping for successful treatment in the hospital doesn’t give the full picture of the effects of COVID-19,” he said. “Our recommendation at this point is to take preventive measures like vaccinations to prevent serious COVID-19 episodes.”

References

Mainous AG et al. Front Med. 2021; doi: 10.3389 / fmed.2021.778434.

Survivors of severe Covid-19 may have an increased risk of death within 12 months of becoming ill. https://www.eurekalert.org/news-releases/936158. Published December 1, 2021. Accessed December 20, 2021.

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