A recent study led by researchers from the University of Kentucky College of Medicine and the College of Health Sciences found that resistance training had unique fat loss benefits. The study by the Department of Physiology and the Center for Muscle Biology published in the FASEB Journal found that resistance-like exercise regulates fat cell metabolism at the molecular level.
The study results in mice and humans show that in response to mechanical stress, muscle cells release particles called extracellular vesicles, which instruct fat cells to switch to fat-burning mode. Extracellular vesicles were originally thought of as a way for cells to selectively eliminate proteins, lipids and RNA. Recently, scientists discovered that they also play a role in intercellular communication.
The study adds a new dimension to the communication of skeletal muscles with other tissues through the use of extracellular vesicles, says John McCarthy, Ph.D., study author and associate professor in the UK Department of Physiology. “To the best of our knowledge, this is the first demonstration of how strength training induces metabolic adjustments in adipose tissue, which is critical in determining metabolic outcomes throughout the body,” said McCarthy. “The ability of extracellular vesicles triggered by resistance exercise to improve lipid metabolism has significant clinical implications.”
McCarthy’s research team was led by postdoc Ivan Vechetti, now at the University of Nebraska, in collaboration with the Center for Muscle Biology under the direction of Joseph Hamburg Endowed Professor Charlotte Peterson, Ph.D. (ANI)
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