January 25, 2022
1 minute read
Source/Disclosures
Disclosure:
Aharon does not report relevant financial information. The relevant financial information of all other authors can be found in the study.
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According to a study published in Obstetrics & Gynecology, researchers found no associations between Pfizer-BioNTech’s and Moderna’s mRNA vaccines and negative effects on early pregnancy stimulation or outcome in IVF.
“This is one of the largest studies reviewing fertility and IVF cycle outcomes in patients who received COVID-19 vaccinations,” author Devora A. Aharon, MD, a fellow in reproductive endocrinology and infertility at Icahn Mount Sinai and Reproductive Medicine Associates of New York, said in a press release.
Devora A.Aharon
Researchers conducted a retrospective cohort study involving patients at the RMA in New York who underwent controlled ovarian hyperstimulation or single euploid freeze-thaw embryo transfer between February and September 2021.
The new study builds on results reported in October 2021 at the ASRM Scientific Congress & Expo, which involved a smaller number of patients studied between February and July 2021.
Vaccinated patients had received two doses of Pfizer’s BioNTech or Moderna vaccines at least 14 days prior to starting their fertility treatments.
In an adjusted analysis, Aharon and colleagues found no association between COVID-19 vaccination and fertilization rate (B = 0.02 ± 0.02) among the 222 vaccinated and 983 unvaccinated patients who had controlled cycles of ovarian hyperstimulation.
The researchers also found no association between the COVID-19 vaccination and egg retrieval (B=0.01 ± 0.57), mature oocytes removed (B = 0.26 ± 0.47), ratio of mature oocytes (B = 0.02 ± 0.01), blast rate (B = 0.02 ± 0.02) or euploid rate (B = 0.05 ± 0.03).
In addition, the researchers examined associations between vaccination and pregnancy, defined as a positive pregnancy test in blood tests; clinical pregnancy, defined as pregnancy visible on ultrasound; and ongoing pregnancy, ie, a healthy pregnancy that has continued with discharge to the obstetrician at approximately 8 to 9 weeks gestation.
Researchers found no association between COVID-19 vaccination and clinical pregnancy (adjusted OR=0.79; 95% CI, 0.54-1.15) in the 214 vaccinated and 733 unvaccinated patients who had a single euploid freezing thawed embryo transfers, with no statistically significant differences between groups. The odds haven’t changed because of the vaccination.
In addition, there was no significant association between COVID-19 vaccination and pregnancy (aOR = 0.88; 95% CI, 0.58-1.33), ongoing pregnancy (aOR = 0.9; 95% CI, 0 .61-1.31), biochemical pregnancy loss (aOR = 1.21; 95% CI, 0.69-2.14), or clinical pregnancy loss (aOR = 1.02; 95% CI, 0.51-2.06 ).
“This study found no significant differences in response to ovarian stimulation, oocyte quality, embryo development, or pregnancy outcome between vaccinated and non-vaccinated patients,” said Aharon. “Our finding that vaccination did not affect these outcomes should be reassuring for those trying to conceive or in the early stages of pregnancy.”
Relation:
- Aaron D., et al. obstetrics 2022;doi:10.1097/AOG.0000000000004713.
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