Infectious Disease

Report suggests transmission of pan-resistant C. auris strains in US hospitals

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Lyman does not report any relevant financial information. Please refer to the study for all relevant financial information from the other authors.

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A new report provides the first evidence that pan-resistant strains of Candida auris may have been transmitted in US hospitals, researchers said.

The report, published this week in MMWR, describes two independent clusters of pan- or echinocandin-resistant C. auris cases in patients with overlapping inpatient exposures and no echinocandin use. The cases were discovered in Washington, DC and Texas between January and April this year.

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Pan-resistant C. auris strains could have been transmitted in US hospitals. Source: Adobe Stock.

“Echinocandin resistance is a worrying threat to clinical and public health, especially when coupled with resistance to azole and amphotericin B (pan resistance).” Meghan Lyman, MD, a medical officer in the CDC’s Mycotic Diseases Division, and colleagues wrote.

“Pan-resistant C. auris isolates have previously been reported, albeit rarely, from the United States and other countries,” they wrote, adding that three pan-resistant C. auris cases reported in New York “after Echinocandin- Treatment resistances developed and were absent “. epidemiological links or universal health care, suggesting that resistance is due to antifungal pressure rather than human-to-human transmission.

According to Lyman and colleagues, of 101 cases of C. auris detected in Washington during the 4 month period, three isolates identified by skin colonization screening at a long-term care facility for critically ill patients were pan-resistant.

In Texas, two out of 22 cases of C. auris detected over the same time period in two facilities with patients in the same city were pan-resistant and five were resistant to both echinocandins and fluconazole, Lyman and colleagues reported.

“These two simultaneous, independent clusters of pan- or echinocandin-resistant C. auris cases in patients with overlapping inpatient health exposure and without prior echinocandin use provide the first indication that pan- or echinocandin-resistant C. auris strains were could be transmitted in US healthcare facilities, ”the researchers write. “Monitoring, public health reporting and infection control measures are critical to containing further spread.”

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