A stroke is the most frequent neurologic complication of APS, and produces the most serious consequences.4 They can occur in any vascular region of the brain, and women are more likely to be affected than men. Patients who are APL-positive also tend to be younger compared with other patients with stroke who are APL-negative, with at least 20% of these strokes occurring in people <45 years. People who have APS secondary to SLE may be at higher risk for stroke.6 The risk for recurrence in primary APS may be higher, but this is not well established.4,5