Neurological

Polygenic risk scores and COPD medical history predict the severity of COVID-19 disease

Patients with a higher polygenic risk score (PRS) or a history of chronic obstructive pulmonary disease (COPD) were more likely to have severe COVID-19, according to a study recently published in the Annals of the American Thoracic Society.

A polygenic risk score was calculated for study participants using 112 single nucleotide polymorphisms believed to be related to the severity of COVID-19 disease. Any history of chronic obstructive pulmonary disease was also included in the overall risk. Logistic regression models were then used to examine relationships between genetic risk and / or COPD and the severity of COVID-19 disease.

Of the 430,582 participants in the UK biobank study, 712 developed severe COVID-19 during the study. Of these 712, 19.8% had pre-existing COPD. When comparing polygenic risk scores, those with low risk scores had a lower chance of developing severe COVID-19 compared to the groups with medium or high polygenic risk.

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The study’s authors wrote, “The PRS, which combines multiple risk alleles, can be effectively used in screening for high-risk populations with severe COVID-19.” They added, “A high genetic risk correlates with a higher risk for severe COVID-19, regardless of a pre-existing COPD. “

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QM Huang, PD Zhang, ZH Li et al. Genetic risk and COPD independently predict the risk of a serious COVID-19 incident. Ann Am Thorac Soc. Published online July 9, 2021. doi: 10.1513 / AnnalsATS.202102-171OC

This article originally appeared on Pulmonology Advisor

Subjects:

COVID19 General Infectious Diseases General Medicine General Pneumology

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