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Symptoms of strep throat are a common sign of multisystem inflammatory syndrome in children, a serious medical condition associated with SARS-CoV-2 infection, researchers reported in the Journal of the Pediatric Infectious Diseases Society.
Elan Jenkins, MD, an assistant professor of pediatrics at Emory University School of Medicine, and colleagues identified 137 children diagnosed with MIS-C at Children’s Healthcare of Atlanta between March 2020 and January 20, 2021.
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Of the 137 patients diagnosed with MIS-C, 39 (28.5%) had neck-related symptoms, with 38 patients reporting neck pain. Three patients had trismus and five reported drooling, difficulty swallowing, or difficulty swallowing, according to Jenkins and colleagues.
Twelve patients underwent neck imaging and four had evidence of retropharyngeal edema / inflammation. All patients treated for retropharyngeal edema were 13 years of age or older.
According to the authors, retropharyngeal edema has been documented in Kawasaki disease and compared with MIS-C. All MIS-C patients with retropharyngeal edema were 4 years of age or older, “which does not correspond to the typical epidemiological distribution of a purulent retropharyngeal infection,” wrote Jenkins and colleagues.
They noted a recent study from the UK that included frequent reports of neck pain in patients with MIS-C and a US study that found neck pain was associated with a higher likelihood of MIS-C than other febrile illnesses.
“In summary, neck symptoms are a relatively common manifestation of MIS-C and could be viewed as a separate clinical system associated with its diagnosis,” wrote Jenkins and colleagues.
References:
Carlin RF et al. J Pediatr. 2021; doi: 10.1016 / j.jpeds.2020.10.013.
Cheong-RCT et al. JAMA Otolaryngol Head and Neck Surgery. 2021; doi: 10.1001 / jamaoto.2020.5698.
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