People with certain autoimmune diseases, such as Crohn’s disease, probably shouldn’t eat nutritional yeast.
Thousands of years ago some yeast flowed into our flour and drinks, which delighted our palates, and we went there regularly exposed since then. Yeast is not a problem for most people, but even non-disease-causing microbes can potentially trigger autoimmune diseases such as Crohn’s disease in car recipients because their finely tuned immune imbalance is somehow disrupted. Maybe that’s why Baker to have the highest Crohn’s disease mortality and from another dataset as well to have among the highest rates of Crohn’s disease as you can see at 0:30 in my video Is Yeast Healthy For Everyone? Perhaps a “hypersensitivity to baker’s yeast … can play a role in Crohn’s disease. “
If you take people with Crohns and remove If you remove the three foods you seem to have the most antibodies to from your diet in an attempt to calm your disease down, and then add those foods back in, you can provoke the symptoms again and stimulate the inflammation again. For example, an anal fistula becomes nice and dry from these foods, starts oozing again as soon as the foods are back on the diet, and then the cone is turned off again when the foods are removed, as you can see (ew!) at 0:57 in mine Video.
However, without a control group, you cannot rule out the possibility of a strong placebo effect. There were no such randomized controlled trials until researchers came up with a brilliant design. they checked People with Crohn’s disease looked for antibodies to 16 different foods and randomized the subjects into two groups. Both groups were instructed to avoid four foods, but one group was instructed to avoid the four foods to which they responded most, while the other group was instructed to avoid the foods to which they were least responsive. The group assignments were given in sealed envelopes so that no one knew who was in which group until the end. So did it matter? Yes, more than twice the likelihood of greater clinical improvement was seen in the group who were told to stay away from the four foods their blood reacted to the most – but it wasn’t just yeast. In fact, “excluding milk, pork, beef, and egg was most closely linked to improvement,” leading researchers to conclude that perhaps instead of failing blood tests, we should just tell our patients to cut out meat and eggs and see how they do it. This would be consistent with population studies that associate “Diets with high animal fat content” with an increased risk of inflammatory bowel disease and interventional studies demonstrate that a plant-based diet that reduces meat to about one serving every two weeks can bring the relapse rate down to an exceptional 8 percent over two years.
But what about the whole yeast question? Can’t you just stick some yeast up someone’s butt and see what happens? Why yes! Yes, you and researchers can have that. Indeed, researchers checked rectal exposure to six different foods, including yeast, in patients with Crohn’s disease. This was like a skin prick test, but instead of pricking the skin, they stabbed people’s rectum with various foods. You can see in mine at 3:00 Video the different prick points for the different foods, and it is clear that yeast showed the most significant response in Crohn’s patients.
It appears This baker’s yeast, which is the same yeast as brewer’s yeast and nutritional yeast, may be disease-causing in Crohn’s disease, but the good news would be that it “may be of therapeutic relevance”. If Crohn’s patients were on a yeast-free diet, would they feel better? You don’t know until you put it to the test.
This is exactly the original study linking yeast and Crohn’s disease recommended as early as 1988. “A controlled trial of a yeast-free diet for patients with Crohn’s disease may therefore be worthwhile.” Why did it take years to conduct such a study? Well who is going to fund it? Big Soda Bread? Fortunately, there are charities like the National Association for Colitis and Crohn’s Disease willing to do this put Beat the (yeast-free) dough.
Nineteen patients with Crohn’s disease ate a regular diet for a month and then switched to a yeast-exclusion diet. There was a significantly higher CDAI, the Crohn’s Disease Activity Index, which rates symptoms such as abdominal pain and diarrhea during the time they ate yeast compared to the time they were without yeast. So there was worse disease activity with yeast than without. Okay, but what was this yeast free diet? They didn’t just cut out bread and beer. For example, the researchers switched from milk to soy milk and from white flour to whole wheat. Straight To cut Our milk can sometimes help with inflammatory bowel disease as you can see in mine at 4:43 a.m. Video.
With so many dietary changes, how do we know what role yeast played? So we know what role yeast played: after placement The subjects on the new yeast-free diet then challenged those affected by Crohn’s with either a yeast capsule or a placebo. A tiny amount of yeast, like a quarter teaspoon of nutritional yeast per day, made it worse, suggesting that “yeast may be important in pathogenesis [disease process] of Crohn’s disease. “
For the vast majority of people, yeast is not a problem, but in susceptible people it can trigger an abnormal immune response in the gut. But wait. I thought the paratuberculosis bug was a trigger for Crohn’s disease. Well, perhaps paraTB infection is what “triggers a hypersensitivity reaction to dietary yeast”. Who knows? The bottom line is that people with Crohn’s disease should Don’t bother adding baker’s, brewer’s, or nutritional yeast to your diet.
I introduced this topic in Does nutritional yeast cause Crohn’s disease?, then took a bit of a tangent with it Is Candida Syndrome Real?. Next, I’ll end this series of videos by talking about another autoimmune disease that appears to be affected: Dietary Cure for Hidradenitis Suppurativa.
For more information on Crohn, see Prevention of Crohn’s Disease with Diet and Dietary treatment for Crohn’s disease.
And paratubercuwhat? See Does paratuberculosis cause type 1 diabetes in milk? and Does paratuberculosis cause type 1 diabetes in meat?
Michael Greger, MD
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