Intermittent fasting didn’t cut back stomach fats in mice

“While most people would think that all adipose tissue is the same, location actually makes a huge difference,” said Larance of the Charles Perkins Center and the University of Sydney’s School of Life and Environmental Sciences.

“Our data shows that both visceral and subcutaneous fat experience dramatic changes during intermittent fasting,” added Larance.

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Adipose tissue provides energy during fasting by releasing fatty acid molecules. However, the researchers found that visceral fat became resistant to this release.

There was also evidence that visceral and subcutaneous fat increased their ability to store energy as fat and likely rebuilt fat reserves quickly before the next period of fasting.

According to Larance, it is possible that visceral fat can be preserved through repeated fasting.

“This suggests that visceral fat can adapt to repeated fasting attacks and protect its energy stores,” he said. “This type of adjustment may be why visceral fat can become resistant to weight loss after long diets.”

The research was done in mice because “mouse physiology is similar to humans, but its metabolism is much faster, so we can see changes faster than human studies and examine tissues that are difficult to extract in humans,” Larance said .

He added that the results may not apply to the 5: 2 diet (fasting two days out of seven) or the calorie restriction that is common in people trying to lose weight.

The results were published in Cell Reports on Wednesday.

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