Neurological

Genetic risk no better for predicting schizophrenia outcomes

Subjects ” Neurological behavior disorders

HealthDay News – For adults with schizophrenia (SCZ) and related psychotic disorders, the polygenic risk score (PRS) does not improve the performance of outcome predictive models, according to a study published online in Nature Medicine Sept. 6.

Isotta Landi, Ph.D., of the Icahn School of Medicine at Mount Sinai, New York City, and her colleagues used data from two multiethnic cohorts comprising a total of 8,541 adults with SCZ and related psychotic disorders to predict outcome with the SCZ-PRS and / or clinical features recorded in a standard psychiatric interview. Data from 762 SCZ patients from the BioMe BioBank program of the Mount Sinai Health System and from 7,779 patients from the Genomic Psychiatry Cohort were included.

The researchers found that the SCZ-PRS did not improve the performance of predictive models for all of the endpoints studied. This observation was robust to divergent case definitions and ancestors of the participants.

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“Our results suggest that more work needs to be done to harness the potential of genetics to improve the treatment of schizophrenia patients,” a co-author said in a statement. “The results also suggest that the detailed medical reports that doctors write may contain much more valuable and predictive information than we originally expected.”

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Neurological behavioral disorder schizophrenia

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