Liver disease for metabolic and bacterial reasons is a growing problem. What do these points have in common? The intestine, or more precisely bacteria in the intestine. Bacteria that cause inflammation in the mouth are transported through the digestive tract to the intestines and liver, where they can cause inflammation of the liver. Lipopolysaccharides, important structural molecules in some bacteria, act as endotoxins and create systemic effects that can manifest as non-alcoholic fatty liver disease (NAFLD). A multidisciplinary team from Tsukuba University is now showing that exercise can be used to improve the oral environment in people with NAFLD, potentially leading to a new treatment for the disease.
These researchers have previously shown that exercise benefits patients with NAFLD by reducing fat, inflammation, and scarring in the liver. Improving the liver’s response to and clearance of the endotoxin; and reducing gum disease. With the latest study in their series, they add another signpost to Neuland.
“We know that exercise as a whole and for these specific conditions has innumerable health benefits,” says author Professor Junichi Shoda. “With this study, we wanted to characterize the underlying mechanisms, that is, show how movement changes physiology and how changing physiology induces changes in oral bacteria.”
Researchers performed biochemical and genetic analyzes of the saliva of obese men with NAFLD and gum disease before and after 12-week exercise or diet programs. Men in both groups were able to lose fat mass, but those who followed dietary restrictions also lost muscle mass, while those who followed the exercise program gained muscle mass. “More importantly, we found that reductions in lactoferrin, lipopolysaccharide, and IgA levels were only noticeable in the men who followed the exercise program,” explains Professor Shoda, “suggesting that the oral environment was changing has changed significantly through training. “
The samples from the exercise group also showed increased bacterial diversity and changes in the relative bacterial constituents. In the general population, more bacteria expressed genes related to environmental information processing and fewer bacteria expressed genes related to genetic information processing and metabolism. In fact, bacteria expressed fewer genes that make lipopolysaccharides.
“Hence, it appears that exercise in people with non-alcoholic liver disease and gum disease causes a biochemical shift in the oral environment that favors the survival of less harmful bacteria,” explains Professor Shoda.
A better understanding of how to reduce the population or harmful effects of certain bacteria in patients with liver and periodontal disease could potentially lead to the development of new and improved treatment strategies for these diseases and other conditions believed to be caused by bacteria how inflammation is affected bowel disease.
Uchida F., Oh S., Shida T. et al. Effects of exercise on the oral microbiota and saliva of patients with non-alcoholic fatty liver disease. Int. J. Environ. Res. Healthcare. 2021; 18 (7): 3470. doi: 10.3390 / ijerph18073470
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