Detox Sequencing – The Key to Better Results

Detox sequencing and implementation of focused phases honors Hippocrates’ ‘do no harm’ principle

Detox has always been part of the natural health approach to wellness that led to modern day detox sequencing. Ancient texts that taught purification and fasting, eclectic and naturopathic practices emphasized purification, homoeopathic philosophy quotations remove “morbid influences” and ancient Chinese and Ayurvedic texts cite to cleanse the cells of undesirable metabolic buildups.

The body still needs this ancient wisdom to support its innate self-cleaning processes – more than ever. But today the game has changed. New challenges, insightful reflections, and far-reaching scientific discoveries all point to functional changes in cleaning modern humans to improve energy, health, and longevity.

What has changed?

First and foremost, we look at changes in the gut microbiome. Modern science has not only discovered the enormous interactions between the intestinal microbes, the brain, immune performance and cellular metabolic functions,[1] but the tandem effect of antibiotics in the food supply[2] and changes in the quality of food have created an altered “functional organism” in the human body.[3]

Today, millions of tons of carcinogens in the global air supply are dysregulating innate health processes.[4] Tap water contains hundreds of chemicals, including chlorine, fluoride, chloramines, pesticides / herbicides, and Rx drugs.[5] Electromagnetic frequencies that interfere with the cell membrane, such as 5G, smart meters and WIFI signals, change the voltage-controlled ion channels of the cell membrane.[6]

What worked in the past can still work today, but the risks are higher and the necessary finesse is paramount. This is why detox phase strategies are so important:

  • Improper fasting can disrupt cellular metabolism and cause immunological confusion[7] [glucose and free-radical processes can raise inflammation].
  • WIFI means more permeable blood-brain barriers and altered cell membrane processes [toxins need to be chelated and move more quickly out of the body].
  • Nuclear radiation particles can penetrate deeper into the bones if they are improperly released from the fatty tissue[8] [specific support required].
  • Cells that are hampered by various gene risk alleles (MTHFR, PON1, CYP1A2) can make their performance difficult.
  • Forced cleansing can overload the liver, making toxins more of an impact on the brain.
  • Medical therapies (vaccines, drugs) risk toxic adjuvants that are linked to autoimmune reactions due to molecular mimicry[9] when the body does not detoxify them effectively.

Put simply, humans are exposed to a wide variety of environmental influences and need specific strategies for effective and harmless detoxification. The body must use its genetically established methods to maintain tissue purity and effective function. This requires updated detox strategies – a collaborative effort between the struggling cell and chiropractic / nutritional health practices.

Old vs. New Detox

In 1980, the versatile A. Stuart Wheelwright saw firsthand that the old detox methods caused more Herxheimer reactions (exacerbations from toxin dumping). He expressed concern that toxins could cross the blood-brain barrier due to a leaky gut.

Today science shows that leaky gut is leaky. The mechanism mentioned is zonulin, a molecule that opens the intestinal tight junctions for the immune system to access the intestines.[10] However, certain pathogenic bacteria can also release zonulin (leaky gut) and this says “open sesame seeds” to the brain barrier.[11]

This is of particular concern as bowel dysbiosis increases neurological susceptibility to the SARS-CoV-1 virus by allowing easier access to the brain.[12]

Wheelwright came up with a new plan: instead of forcing a detox, he said, “First build liver function with plant compounds so the liver can naturally handle a larger load of toxins.”

What began as a new detox movement in the 1980s is necessary today. With refinements of the gut microbiome, reflection on a person’s unique genes, and a deeper scientific understanding of the body’s “drainage” pathways, a simple, all-encompassing detox sequencing strategy takes into account each person’s biochemical uniqueness and individual circumstances.

Nature is abundant in detox support. More recently, clinical nutritionists have been using glutathione and methylfolate / methylcobalamin[13] to support the body’s natural, cellular waste disposal systems.

Detox sequencing phases

Phase one – preparation. The detox should begin with a “preparation phase”. Here we find diet changes towards healthier, organic foods and the elimination of inflammatory and denatured foods, e.g. B. Processed foods such as counterfeit meat products, alcoholic beverages, sugary foods, and commercial meats, dairy products, and grains.

In the preparation phase, we consider the downstream cleaning processes. The most important paths include:

  1. The liver-gallbladder Processes that detoxify the body through the intestines. Increasing liver function helps support the increased workload of detoxification. The liver benefits from antioxidants and phytonutrients.
  2. Gut microbiome. Pre- and probiotic support helps the body to lower the inflammation setpoint (less leaky gut).
  3. Cell membranes. Often damaged and inflamed, which hinders the absorption of nutrients and the escape of toxins. Damaged mitochondrial membranes struggle to produce ATP (adenosine triphosphate) energy.
  4. Mitochondrial (ATP) processes. Detoxification and detox sequencing cannot be performed without ATP. Detox is really about restoring mitochondrial health.
  5. Cellular methylation. Necessary for intracellular, metabolic detoxification.
  6. Kidneys. The liver often sends water-soluble molecules to the kidneys for removal. The kidneys serve as a drainage support.

Phase two – extracellular matrix (ECM) support. It just makes sense to next help with detoxifying the “memory dumps” in adipose tissue and in the ECM. Clean the “low hanging fruit” and open the drainage channels.

Phase Three – Intracellular Metabolic Support. The next pecking order is for real cellular detox. This expands the benefits of the prep phase to include continuous cell membrane support, methylation / antioxidants, and mitochondrial performance. Cells discard acquired and produced toxins that travel to the liver. Glutathione supports the liver, the intestinal microbiome and intracellular processes along with methylation support. As the gallbladder drains toxins into the small intestine, state-of-the-art clinicians use super activated carbon to bind the toxins to prevent absorption downstream.

Brain phase – phase four. Detoxing the brain requires open paths through the body. By initially helping to cleanse the tissues and cells and create drainage pathways, the brain’s glyphatic system begins to remove acquired and formed toxins and direct them to the lymphatic and blood systems, which are ready to do the job. A squeaky clean brain can better regulate the body’s activities, including GI motility and the immune system.

Today’s environment of new toxins and EMF interference requires new strategies for safe and effective detoxification. Chiropractic with clinical nutritional strategies primarily serves to support neurological and metabolic health for the innate life processes of the body. Detox sequencing and the implementation of focused phases honors Hippocrates “Do no harm” principle and adapts the age-old self-cleaning processes to the challenges of modern life.

JACK TIPS, known as The WellnessWiz, is a clinical nutritionist, homeopath, and herbalist with over 40 years of clinical experience. His specialties are homogenomics (gut microbiome and genetics), detoxification and intracellular metabolic activities. As the author of 16 books and hundreds of research reports, his publications are featured on

[1] Tomasova, L., Grman, M., Ondrias, K. et al. The Influence of Intestinal Microbiota Metabolites on Cellular Bioenergetics and Cardiometabolic Health. Nutr Metab (London) 18 72 (2021).

[2] Franciscan MP. Antibiotics and the human gut microbiome: dysbiosis and accumulation of resistance. Microbiol. 2016 Jan 1; 6: 1543. doi: 10.3389 / fmicb.2015.01543. PMID: 26793178; PMCID: PMC4709861.

[3] RK Singh, HW Chang, D. Yan et al. Influence of diet on the gut microbiome and effects on human health. J Transl. Med. 2017; 15 (1): 73. Published on April 8, 2017 doi: 10.1186 / s12967-017-1175-y

[4] Kessler, R. Prevention: Danger. Nature 509, S62-S63 (2014).

[5] Harvard Heatlh Publishing, Harvard Meical School, Drugs in Water, June 2011

[6] Martin L. Pall, Wi-Fi is a Major Threat to Human Health, Environmental Research, Volume 164, 2018, Pages 405-416, ISSN 0013-9351; (

[7] Alissa Fleck, The Cons of Fasting, SFGate, December 12, 2018

[8] Walker, Stuart, U.S. Environmental Protection Agency, EPA Facts About Strontium-90,

[9] Segal, Y., Shoenfeld, Y. Vaccine-Induced Autoimmunity: The Role of Molecular Mimicry and Cross-Immune Reaction. Cell Mol Immunol fifteen, 586-594 (2018).

[10] Rahman, Ghosh, Hossain, Linfield, Rezaee, Janigro, Marchi, van Boxel-Dezaire, IFN-γ, IL-17A or zonulin quickly increase the permeability of the blood-brain and small intestine epithelial barrier: relevance for neuroinflammatory diseases, biochemical and biophysical Research Communications, Volume 507, Issues 1–4,

2018, pages 274-279, ISSN 0006-291X,

[11] Fasano A. Zonulin, regulation of tight junctions and autoimmune diseases. Ann NY Acad Sci. 2012; 1258 (1): 25-33. doi: 10.1111 / j.1749-6632.2012.06538.x

[12] Sílvia, Nava, Muñoz-López, Álvaro, Segura, Neurological Symptoms of COVID-19: The Zonulin Hypothesis

Frontiers in Immunology, Vol. 12, 2021, p. 1344,

DOI = 10.3389 / fimmu.2021.665300 ISSN = 1664-3224

[13] Romilly E. Hodges, Deanna M. Minich, “Modulation of Metabolic Detoxification Pathways with Food and Food-Derived Components: A Scientific Review with Clinical Application,” Journal of Nutrition and Metabolism. vol. 2015, Entry ID 760689, 23 pages, 2015.

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