Infectious Disease

Depression, depressive symptoms that occur with long-term COVID. are common

October 18, 2021

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Renaud-Charest does not report any relevant financial information. Please refer to the study for all relevant financial information from the other authors.

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Depressive symptoms and clinically significant depression were common more than 12 weeks after SARS-CoV-2 infection, according to a systematic review published in the Journal of Psychiatric Research.

“Recent reviews have examined the neuropsychiatric consequences of COVID-19, but to the best of our knowledge, none have reported the incidence of depression, particularly in accordance with [National Institute for Health and Care Excellence]-defined post-COVID-19 syndrome “, Olivier Renaud-Charest, from the University Health Network at the University of Toronto and the Faculty of Medicine and Health Sciences at McGill University, and colleagues wrote. “Still, studies of survivors of the Severe Acute Respiratory Syndrome (SARS) pandemic in 2003 indicated the presence of depression for up to 12 months after hospital discharge. Hence, it can be hypothesized that depression is a significant outcome in survivors of coronavirus infections. “

Renaud-Charest and coworkers reviewed six uncontrolled observational studies and two prospective cohort studies published between January 1, 2020 and June 5, 2021 that confirmed a reverse transcriptase polymerase chain reaction (RT-PCR) related to COVID-19 Symptoms and clinical depression studied with depressive illness.

Of the eight studies, five scored high on the Newcastle-Ottawa Scale (NOS) and three had moderate NOS scores.

The frequency of symptoms of depression over 12 weeks after infection ranged from 11 to 28%, and the rates of clinically significant depression ranged from 3 to 12%.

While most studies rated depression 3 or 4 months after diagnosis or discharge, one study rated depressive symptoms and the severity of depression 6.5 months after discharge from hospital, with a rate of 27% for moderate symptoms and 5% for severe symptoms was noted.

Depression was associated with females, prior psychiatric diagnosis, psychopathology at 1 month, and systemic inflammation during the acute phase; The age is only a potential factor and the severity of the acute COVID-19 is not, wrote Renaud-Charest and colleagues. Depression remained prevalent at follow-up visits at 1 and 3 months, although PTSD symptoms, anxiety, and insomnia decreased between these times.

The severity of depressive symptoms was proportional to the underlying systemic inflammation, which “explained the variation in severity of depression in models assessing the influence of age, gender, and hospitalization,” they wrote.

Neurocognitive function did not moderate depression in acute COVID-19, but depressive symptoms significantly affected neurocognitive function in post-COVID-19 syndrome.

Limitations included heterogeneous study designs, lack of controls, and no assessment of baseline depression or previous acute infection.

Roger McIntyre

“We now know that depressive symptoms are a major component of post-COVID consequences,” study author Roger McIntyre, MD, FRCPC, from the University Health Network of the University of Toronto, the Institute of Medical Science and the Departments of Pharmacology and Toxicology and Psychiatry, told Healio Psychiatry. “We should be vigilant about the possibility of suicidality associated with the aftermath of post-COVID, and future research should seek to better understand the underlying neurobiology. Perhaps the neurobiology of the post-COVID episode overlaps with major depression. “

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