COVID-19 vaccines are well tolerated by women of reproductive age

HealthDay News – COVID-19 vaccines are well tolerated by people who are pregnant, breastfeeding, or planning to conceive, according to a research letter posted online on JAMA Network Open on Aug. 17.

Alisa Kachikis, MD, of the University of Washington in Seattle, and colleagues surveyed women who were pregnant (7,809 participants), breastfeeding (6,815 participants), or planning to become pregnant (2,901 participants) at the time of the COVID-19 vaccination for demographics (including race and ethnicity), pregnancy, vaccination awareness and outcome data, including a report of vaccination reactions on the first day.

The researchers found that 97.0 percent of respondents reported any post-vaccination reactions after the first dose, with the most common reactions being injection site pain (91.4 percent) and fatigue (31.3 percent). After the second dose, the frequency of reactions was higher than after the first dose (69.2 percent with fatigue after the second dose), but with a similar distribution of symptoms. Respondents who were pregnant had a significantly reduced likelihood of multiple reactions (e.g. fever after Pfizer BioNTech dose 2: odds ratio 0.44; after Moderna dose 2: odds ratio 0.48) compared to individuals who were neither pregnant nor breastfeeding. All obstetric symptoms were reported by 4.4 percent of pregnant women after the first dose and 7.5 percent after the second dose.

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“One of the limitations of the study is that participants were drawn from a random sample of self-reported reactions and with limited perinatal outcome assessment, reflecting the first wave of vaccinations that consisted primarily of health workers due to the vaccination eligibility at the time,” the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Pfizer.

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