The Denver City Council recently passed an ordinance to allow the nation’s first supervised injection site. The Colorado General Assembly must also render an approval. A bipartisan bill to allow the site narrowly failed in a Republican-controlled Senate in 2018, but party control will change in 2019, making its passage more likely.3 Meanwhile, cities including San Francisco and Philadelphia are moving forward with their own site plans, despite warnings from the US Justice Department. Whether in Denver, San Francisco, Philadelphia, or elsewhere, expect the first supervised injection site in the United States to open in the near future, and for a legal battle to follow.