Subjects ” Vascular neurology
HealthDay News – According to a study published online Jan. 14 in Stroke, evidence suggests a causal link between smoking and the risk of subarachnoid hemorrhage (SAH).
Julián N. Acosta, MD of the Yale School of Medicine in New Haven, Connecticut, and colleagues conducted a one-sample Mendelian randomization (MR) study that used data for participants of European descent from the UK biobank who had more than 500,000 Britons aged 500 years participated 40 to 69 years from 2006 to 2010. A polygenic risk score was created using independent genetic variants known to be related to smoking behavior. This value represents the genetic susceptibility to initiating smoking.
Data were collected for 408,609 study participants, of whom 32 percent had ever smoked regularly and 0.22 percent had SAH. The researchers found that each additional standard deviation in the polygenic risk score for smoking was associated with a significantly increased risk of smoking (odds ratio, 1.21) and a significantly increased risk of SAH (odds ratio, 1.10) was. The genetic susceptibility to smoking was associated with an increase in the risk of SAH in the primary MR analysis (odds ratio, 1.63) using the ratio method. Similar results were obtained in secondary analyzes using the inverse variance-weighted method and the weighted median method (odds ratios, 1.57 and 1.74, respectively).
“Our results warrant future studies to investigate whether information about genetic variants that lead to smoking can be used to better identify people at high risk for any of these types of brain hemorrhage,” Acosta said in a statement. “These audiences could benefit from aggressive diagnostic interventions that could lead to early detection of the aneurysms that cause this severe type of bleeding stroke.”
One author announced financial ties to the biopharmaceutical and medical device industries.
Abstract / full text
Smoking subarachnoid hemorrhage, vascular neurology
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