Neurological

ADHD linked to Alzheimer’s disease across generations

Subjects ” Alzheimer’s and dementia

HealthDay News – According to a study published online September 9 in Alzheimer’s & Dementia, there has been an association between attention deficit / hyperactivity disorder (ADHD) with Alzheimer’s disease (AD) and any dementia across generations.

Le Zhang from the Karolinska Institutet in Stockholm and colleagues investigated the extent to which ADHD is linked to AD and all dementia over generations. Swedish national registers were used to link a nationwide cohort born between 1980 and 2001 to their biological relatives (parents, grandparents, uncles / aunts). Cross-generational associations were examined with Cox models.

The researchers found that 3,042 parents, 171,732 grandparents, and 1,369 uncles / aunts of 2,132,929 index people had a diagnosis of AD. The risk of AD was increased in parents of people with ADHD (hazard ratio 1.55; 95 percent confidence interval 1.26 to 1.89). The associations were weakened with decreasing genetic relationship, but remained increased in the grandparents (hazard ratio 1.11; 95 percent confidence interval 1.08 to 1.13). A stronger association was observed for early versus late onset AD. The results were similar for each dementia.

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“The results suggest that there are common genetic and / or environmental contributions to the relationship between ADHD and dementia. Now we need more studies to understand the underlying mechanisms, ”Zhang said in a statement.

Two authors disclosed financial ties to the biopharmaceutical industry.

Summary / full text

Subjects:

Alzheimer’s Disease and Dementia Attention Deficit / Hyperactivity Disorder Dementia

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