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Healio Gastroenterology presented the following top peer testing reports in May.
These stories include ACG guidelines for preferred treatment for adults with Clostridioides difficile, updated recommendations from the US Preventive Services Task Force on Colon Cancer Screening, digestive disease week coverage, and more.
ACG publishes guidelines for preferred treatment of C. difficile infection
ACG has developed guidelines for preferential treatment for adults with Clostridioides difficile infection, which have been published in the American Journal of Gastroenterology.
“These guidelines are up-to-date – we referred to new literature until the final revision – and very clinically oriented. [Infectious Disease Society of America and Society of Healthcare Epidemiologists of America] published its own guidelines a few years ago “, Colleen R. Kelly, MD, said Healio Gastroenterology. “We checked our severity categories against theirs – non-severe, severe, and fulminant infections – and decided not to delve deep into the epidemiology and infection control practices that they handled well. Instead, we wanted to develop an evidence-based, clinically useful guideline for the diagnosis, treatment, and prevention of C. difficile infections and have chosen to focus on areas of particular interest to gastroenterologists, including diagnostic questions related to diarrhea and differentiating C. difficile colonization , Expanding from Active Infection and the Assessment and Treatment of CDI in Inflammatory Bowel Disease. ”READ MORE.
USPSTF issues updated recommendations for colorectal cancer screening
The US Preventive Services Task Force has issued updated recommendations for colorectal cancer screening in JAMA.
“Colorectal cancer is a devastating disease and the third leading cause of cancer death in the United States, yet about a quarter of adults ages 50 to 75 have never been screened for colorectal cancer. The Task Force reviews its recommendations approximately every 5 years to ensure that they reflect the latest research. ” Martha Cubic, PhD, RN, Professor and director of the School of Nursing at George Mason University’s College of Health and Human Services, a member of the US Preventive Services Task Force (USPSTF), said Healio. “Screening for colon cancer is effective and saves lives. New scientific knowledge about colon cancer in people under 50 has enabled us to extend our recommendation to people aged 45 to 49 years. Everyone between the ages of 45 and 75 should be screened for colon cancer to reduce their risk of dying from the disease. ”READ MORE.
Use of sugar-sweetened beverages in connection with early onset colon cancer
In women, a higher consumption of sugar-sweetened beverages in adults and adolescents correlated with a higher risk of early-stage colon cancer, according to a study published in Gut.
“Early onset colon cancer (EO-CRC, age <50 at diagnosis) is increasing rapidly in the US, although its aetiology and who contributed to this increase are unclear. Sugar-sweetened beverages (SSBs) have detrimental metabolic effects over the course of life, including insulin resistance and inflammation. Higher SSB intake has also been linked to obesity, which was previously linked to the risk of EO-CRC. " Yin Cao, MPH, ScD, Department of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Healio said. “We therefore assume that SSB may be a new risk factor for EO-CRC and likely contribute to the rising incidence of EO-CRC.” READ MORE.
Association found between family history of colorectal polyps and risk of colorectal cancer
Family history of colorectal polyps associated with a higher risk of colon cancer in a Swedish cohort, according to a study published in BMJ.
“In contrast to the identified increased risk associated with a family history for CRC, it remains unclear whether those with a family history of colorectal polyps are at increased risk for CRC. As a result, the screening recommendations available for people with a family history of polyps are inconsistent. ” Mingyang Song, MBBs, ScD, Department of Epidemiology and Nutrition at Harvard TH Chan School of Public Health and colleagues wrote. “Given the higher prevalence of polyps than CRC, coupled with the increasing prevalence of endoscopic screening, a better understanding of the impact of family history of polyps on CRC risk is critical to improving current screening recommendations.” READ MORE.
Young IBD patients do not develop neutralizing antibodies against SARS-CoV-2
Among the young patients with inflammatory bowel disease, most who were positive for SARS-CoV-2 had a non-neutralizing antibody, as presented on Digestive Disease Week.
“The rapid decline in antibody levels after a SARS-CoV-2 infection in our IBD patients treated with biologics indicates a higher risk of reinfection, especially for variants that can escape the antibodies.” Joelynn Daily, THU, from Connecticut Children’s Medical Center, Hartford, said during her presentation. CONTINUE READING.
Probiotics, reducing symptoms of an upper respiratory tract infection
Daily use of probiotics has been correlated with a reduction in upper respiratory tract infection symptoms in obese individuals, according to a Digestive Disease Week presentation.
“There is growing body of evidence to support the contribution of the gut-lung axis to discovering the relationship between the gut microbiome and respiratory immune responses.” Benjamin Mullish, MD, clinical lecturer in the Digestive Diseases Department, Imperial College London, England, during a press conference outside the DDW. “Previous research in this area shows that probiotics can reduce upper respiratory tract infections (URTIs) in healthy adults and children; However, we have little data on vulnerable populations such as the elderly, overweight and obese. ”READ MORE.
Patients prefer FIT to blood tests for CRC screening
When given the choice, participants preferred fecal immunochemical test-based screening for colon cancer versus a blood test, according to a study presented on Digestive Disease Week.
“Suboptimal participation is common with CRC screening programs; few studies have looked directly at non-participants to test strategies that might be effective in engaging them. Barriers include access to health systems, believing in the value of screening, contacting trusted advocates, reluctance to take certain types of tests, and the inconvenience of doing the screening system yourself. Graeme Young, MD, FRACP, Flinders Center for Innovation in Cancer, Flinders University, said. “Our previous studies have shown that a blood test is overwhelmingly preferred to a FIT for two-step screening. Therefore, a blood test with screening could improve participation, especially for non-participants who previously offered FIT. ”READ MORE.
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