Infectious Disease

AAP updates guidelines for RSV in mid-off-season cases

August 10, 2021

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The AAP released tentative guidance on treating lower respiratory tract infections caused by respiratory syncytial virus during an off-season surge in cases that came with the relaxation of some COVID-19 restrictions.

The provisional guidelines change the timing – but not the risk categories – for the use of palivizumab prophylaxis in infants at increased risk for severe RSV disease and support administration outside the typical RSV season, which usually occurs in autumn and winter . according to AAP.

Source: CDC.gov.

However, RSV activity is currently increasing, the AAP noted.

Mary T. Caserta

“It is a very unusual year, as we all know, and part of the unusual is that RSV infections are now occurring and widespread in different regions of the country, with cases increasing – including cases in children on emergency rooms and hospital stays “, Mary T. Caserta, MD, FAAP, Co-author of the guidelines and professor of pediatrics at the University of Rochester Medical Center, said Healio.

“So many regions in the country are experiencing a number of cases of RSV that resemble a typical winter outbreak,” Caserta said. “So the AAP supports the use of the drugs that we would normally use when these case numbers are now available for high-risk children.”

Palivizumab has been approved since 1988 for reducing severe lower respiratory tract infections caused by RSV in children at increased risk of developing serious illness. Michael T. Brady, MD, FAAP, Chairman of the AAP’s Infectious Diseases Committee and Associate Editor of the Red Book, and colleagues mentioned in the preliminary guidance that supersedes the 2012 Red Book recommendations.

Caserta said the recommendations don’t apply to the upcoming 2021-2022 RSV season. She said the AAP will periodically review the preliminary guidance that can be found here.

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