What were the results of the first randomized controlled trial of nutritional intervention in autism spectrum disorder (ASD)?
At the beginning of my video Gluten-Free, Casein-Free Diets for Autism Put to the Test, I. to discuss the so-called opioid excess theory of autism, which states that certain wheat and milk proteins are proteins takenMorphine-like protein fragments are created, which then enter the bloodstream, enter the brain, and cause neurological damage that can manifest as autism. The theory started as opioid peptides apparently discovered in the urine of children with autism but absent in the urine of children who are developing normally as you can see at 0:27 in my Video. However, a decade later, a more specific test failed to find urine opioid peptides in children with autism. As shown at 0:41 in mine Videowho have favourited Spectral Analysis of Urine in Children with Autism is practically identical to those without autism, so the whole theory was challenged … until an even more sensitive test was found developed.
“Increased levels of circulating casomorphins (CM), the exogenous opioid peptides from [bovine] Milk casein, May contribute on pathogenesis [development] of autism in children. Since casomorphins could not be detected in autistic children in several mass spectrometry studies, this was questioned … “until the researchers were able to demonstrate that autistic children actually have significantly higher concentrations of bovine casomorphins in their urine than children without autism, as you can see at 1:15 in my. can see Video. In addition, the “severity of the autistic symptoms” correlated with concentrations of CM-7 [casomorphins] in the urine. “The more casomorphins they flowed through their bodies, the worse their autism symptoms were. The researchers continued,” Because CMs [casomorphins] interact with opioid and serotonin receptors, the well-known modulators of synaptogenesis “- the formation of nerve-to-nerve connections in the brain -” we suspect that chronic exposure to elevated levels of bovine CMs affects early childhood development and the conditions for Autism can create disorders. “
If increasing exposure to cow’s milk casomorphine opioids correlates with increasing severity of autism symptoms, as you can see at 2:03 in my. can see Videowhy not just give Opioid Blocking Drugs For Children? That’s the medical mentality. Why don’t you try it instead? to treat the cause with nutritional intervention – not just to see if it’s a cause at all, but also to see if we can actually help these children?
It started with case reports such as: “A seven year old girl with autistic behavior who benefited from a gluten and casein free diet…” Notably, “over the course of two years, the girl changed from being very withdrawn to being a normally communicative” child that society saw Another is enjoying. ”Furthermore, her dramatic improvements at one year, then two years, seemed to correlate with decreasing urinary peptide levels, as you can see at 2:54 in mine Video.
Could this one case just have been a coincidence? Some doctors thought it was worth trying and published spectacular results. asserting 80 percent of their child patients with autism improved after three months on a gluten-free, casein-free diet. Even omitting casein, the cow’s milk protein, appeared to lead to “a significant improvement in behavioral symptoms …”. However, none of these studies had a control group. It took until 2002 as the first randomized controlled trial of dietary intervention in autistic syndromes released. Twenty children with autism participated in the study, and half were randomized to a gluten-free and casein-free diet for one year. They were tested before and after. How were those on the diet? “The development in the group of children on the diet was significantly better than in the controls.” Okay, but how was it better?
At 3:51 am in mine Video, you can see the “resistance to communication and interaction” of all 20 children in the study before and after the one-year experiment period. In the control group, two children were better off, two were doing worse, and the others were doing just as badly as at the beginning of the study. However, in the diet group, they all got better. The values for “social isolation” were also tested. In the control group, half got better, while the other half got worse or stayed the same. Everyone in the diet intervention group felt better. Overall, for “total impairment scores for both social isolation and bizarre behavior”, half got better in the control group and half got worse, but all got better in the diet group.
What does it all mean in real life and not just in numbers? “All participants first divided a most common feature of autistic syndromes, the lack of peer relationships. Some ignored other children while others tried to make contact but didn’t know how to interact. Some had abnormal outbursts of anger. Some showed paradoxical and strange emotional expressions, such as laughing when others were crying… ”Also, some children were found to have extreme anxiety in response to common situations. “These unusual emotions were drastically reduced in the diet group, but not in the control group. The inability to see other people’s perspectives and a lack of empathy are also common features of autistic syndromes. Some of the children could suddenly hit or bite others, or make negative remarks … Progress was made in developing empathy in the diet group but not in the control group. Some children even liked and disliked physical contact from their parents. This was in the diet group after [year-long] The trial phase was over. While none of the changes were significant in the control group, [positive] Changes in the peer relationship, fear, empathy and physical contact were registered in the nutrition group. “
This article discusses the third video in a six-part series on the role of gluten and dairy-free diets in the treatment of autism. In case you missed the first two, see and Cow’s Milk Autism and Casein and Does A2 milk have a lower risk of autism?.
Stay tuned for the rest of the series:
Stay tuned to all of my autism related videos Here.
Casomorphins – breakdown products of casein, a milk protein with opiate-like activity – can also play a role in sudden infant death syndrome (SIDS), also known as crib death. See:
In health,
Michael Greger, MD
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