Infectious Disease

“Various Vary” of Coronary heart, Pulmonary and Kidney Issues from COVID-19

December 08, 2020

2 min read

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Murk reports being an advisor and holding shares in Aetion. In the study you will find all relevant financial information from all other authors.

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A large study of patients in the United States diagnosed with COVID-19 shows a wide range of complications, according to new research.

“The most common complications we identified – including viral pneumonia, respiratory failure, acute kidney failure, and sepsis – were expected to be as well described in the literature. We also identified less common complications previously described in case series or small studies, such as: B. Disseminated Intravascular Coagulation, Pneumothorax, Myocarditis, and Rhabdomyolysis, ”William Murk, PhD, MPH, of the Jacobs School of Medicine and Biological Sciences in Buffalo, New York and colleagues wrote in the Canadian Medical Association Journal.

Researchers used U.S. health data from the HealthVerity Marketplace dataset to compare the frequency of ICD-10-CM diagnostic codes that occurred before and after the COVID-19 pandemic outbreak in an exposure crossover design. The researchers calculated risk estimates and OPs of the COVID-19 association for each diagnostic code.

The study included 70,288 patients (mean age 65 years; 55.8% women) who were diagnosed with COVID-19 from March to April. Fifty-three percent of the patients were hospitalized and nearly five percent were admitted to the intensive care unit. New York (19.2%), New Jersey (10.2%), Michigan (9.3%), Pennsylvania (7.5%), and Illinois (7.2%) were the most common residential conditions among those in the study included patients.

A total of 69 of 1,724 ICD-10-CM diagnostic codes were found to be significantly associated with COVID-19 infection.

Viral pneumonia (absolute risk 27.6%; OR = 177.63; 95% CI 147.19-214.37), respiratory failure (absolute risk 22.6%; OR = 11.36; 95% CI 10.74-12 , 02), acute kidney failure (absolute risk) 11.8%; OR = 3.5; 95% CI, 3.34-3.68) and sepsis (absolute risk, 10.4%; OR = 4.23; 95% CI, 4.01-4.46) showed a strong association with COVID-19- Infection and high absolute risk. according to the results.

Acute myocarditis (absolute risk 0.1%; OR = 8.17; 95% CI 3.58-18.62), disseminated intravascular coagulation (absolute risk 0.1%; OR = 11.83; 95% CI 5, 26-26.62) and pneumothorax (absolute risk, 0.4%; OR = 3.38; 95% CI, 2.68-4.26) showed strong associations with COVID-19 infection, but a low absolute one Risk according to the results.

“Although COVID-19 has been widely reported to increase the risk of stroke, this was not seen in our study,” the researchers wrote. “For I63 (“ cerebral infarction ”) in our general population, we observed an OP of 0.58 and an overall risk of 1.5%, which suggests that patients with COVID-19 suffer a stroke with significant frequencies, but a causal relationship having COVID-19 was not supported in this population. “

The researchers found that multisystem inflammatory syndrome in children was not assessed directly due to the lack of a specific ICD-10-CM code.

“After analyzing all possible diagnostic codes, we confirm that COVID-19 is also linked to a variety of additional cardiac, thrombotic and other diseases, although the overall risk for most of these complications is comparatively low,” the researchers wrote. “Understanding the full spectrum of associated diseases can improve prognosis, guide treatment decisions, and better educate patients about their actual risks for the multitude of COVID-19 complications reported in the literature and media.”

The researchers cited limitations of the current study, including identifying COVID-19 cases using diagnostic codes and risk estimates that may be higher than those in the general population, as patients in this study are more likely to have comorbidities.

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