Infectious Disease

The incidence of liver most cancers will increase considerably in individuals with HIV

February 17, 2021

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Sun does not report any relevant financial information. In the study you will find all relevant financial information from all other authors.

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According to a study published in JAMA Network Open, the rate of hepatocellular carcinoma in people with HIV increased significantly from 1996 to 2015.

The study found that people with HIV who were coinfected with viral hepatitis and who had higher levels of HIV RNA, lower CD4 cell counts, or HIV from injectable drug use were at higher risk for hepatocellular carcinoma (HCC).

HIV co-infection graphic

Source: Sun J, et al. JAMA Netw Open. 2021; doi: 10.1001 / jamanetworkopen.2020.37512.

“HCC is among the deadliest cancers worldwide and is one of the few malignant entities with an increasing incidence and mortality in the United States over the past few decades.” Jing Sun, MD, PhD, Assistant Scientists at the Johns Hopkins Bloomberg School of Public Health and colleagues wrote.

“People with HIV had a value more than three times higher [incidence rate (IR)] for HCC compared to the general US population rates observed in the Linkage of Surveillance, Epidemiology and Outcomes and Medicare (0.75 vs. 0.23 cases / 1000 person-years), indicating the increased relative exposure to HCC in people with HIV shows, ”explained the.

Sun and colleagues conducted a cohort study to examine trends in HCC rates and compare risk factors in people living with HIV during the era of combination antiretroviral therapy. The researchers looked at hepatitis B and C virus rates, which increase the risk of developing HCC in people with HIV. This included 109,283 people with HIV aged 18 years or older for whom data on HIV RNA and CD4 cell counts were available.

A total of 19.5% (21,343) of the patients were co-infected with HCV, 5.8% (6,348) were co-infected with HBV, and 1.9% (2,082) had HCV, HBV, and HIV. In addition, 451 patients were diagnosed with HCC by 2015.

Between the early ART combination (cART), defined as 1996 to 2000, and the modern cART era, defined as 2006 to 2015, the IR of HCC increased from 0.28 to 0.75 cases per 1,000 person-years. HCC’s IRs increased from 0.34 cases to 2.39 cases per 1,000 person-years in people co-infected with HIV and HCV between 1996 and 2015. The HCC-IRs increased from 0.65 cases to 4.49 cases per 1,000 person-years in triplicate people infected with HCV, HBC and HIV over the same period.

“It is important to consider other factors and health differences in order to reduce the overall exposure to HCC in aging people living with HIV,” the researchers wrote. “Treatment strategies that focus on HCV screening and early intervention for chronic HCV or HBV in people who inject drugs, as well as long-term management of risk behavior should be further explored.”

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