Infectious Disease

Sufferers with IBD ought to obtain a COVID-19 vaccine regardless of issues

January 26, 2021

2 min read

Source / information

Source:

Ungaro RC et al. Understanding IBD-Related Care in the Age of COVID-19. Presented at: Crohn’s and Colitis Congress (virtual); 21.-24. February 2021.

Disclosure:
Ungaro reports a financial relationship and commercial interest in AbbVie. Received consultation fees for Eli Lily; Receiving consulting fees and grants / research support from Bristol Myers Squibb; Received advisory fees for and advisory boards on the advisory or review boards of Pfizer, Takeda, and Janssen.

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According to a presentation at Crohn’s and Colitis Congress, doctors should encourage patients with inflammatory bowel disease to receive COVID-19 vaccination despite the lack of studies on the cohort.

“For patients with IBD, we would recommend based on [International Organization for the Study of Inflammatory Bowel Disease (IOIBD)]that patients are vaccinated and recognize that there is a lack of data, especially in IBD patients. ” Ryan C. Ungaro, MD, MS, Gastroenterologist from the Feinstein IBD Center at Mount Sinai Hospital, said Healio Gastroenterology. “However, we believe that the benefits weigh the risks and are based on previous experience with vaccination in IBD patients.”

CDC and IOIBD recommend patients with IBD to receive the COVID-19 vaccine.

Abobe floor

Ungaro said the immunocompromised patients recommended by the CDC recommended the COVID-19 vaccine. Patients should be advised that it is not yet known whether the safety and efficacy of the vaccine are equivalent in immunocompromised patients compared to the general population.

“The main concern would be that certain drugs could cause a decreased response to the vaccine,” he said. “This is something that needs to be investigated, but right now the expert consensus is that IBD patients should be vaccinated against COVID-19.”

According to IOIBD recommendations, patients with IBD should receive the COVID-19 vaccine as soon as possible. Messenger RNA vaccines, replication vector vaccines, inactivated vaccines, and recombinant vaccines can be safely administered to IBD patients, Ungaro said.

In addition, the IOIBD said that vaccines should not be postponed if an IBD patient is on immunomodifying therapies.

Ungaro said patients with IBD taking corticosteroids and receiving the vaccine should be advised that there may be a decreased systemic response. He said this must be studied further.

“Prospective studies are planned to examine the effectiveness and side effects of the COVID-19 vaccine in practice in IBD patients,” said Ungaro. “This would require cohorts to be vaccinated and followed. There are studies going on both in the US and internationally. [Surveillance Epidemiology of Coronavirus Under Research Exclusion-IBD (SECURE-IBD)] will also help support some of these efforts. “

Ungaro and his team at Mount Sinai worked with the University of North Carolina in early 2020 to develop the SECURE-IBD ​​registry to monitor and report outcomes of COVID-19 in patients with IBD.

He said, “Doctors can encourage IBD patients to enroll with the Crohn’s and Colitis Foundation’s IBD partners. They will be one of the sources for prospective COVID-19 vaccine studies.”

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Crohns & Colitis Congress

Crohns & Colitis Congress

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