Infectious Disease

Seasonal re-infection of the coronavirus occurs frequently, as study results show

April 03, 2021

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Petrie does not report any relevant financial information. In the study you will find all relevant financial information from all other authors.

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Seasonal coronavirus reinfection is common, according to study results published in the Journal of Infectious Diseases.

The study also suggested that anti-spike protein-binding antibodies did not correlate with protection against seasonal coronavirus infections, researchers said.

Coronavirus reinfection infographic

Source: Petrie JG et al. J Infect Dis. 2021; doi: 10.1093 / infdis / jiab161.

“Doctors should still suspect SARS-CoV-2 infections in their patients with acute respiratory infections, even if that patient was previously infected.” Josh G. Petrie, PhD, Healio said, a research fellow at the Epidemiology Department of the University of Michigan’s School of Public Health. “Given the behavior of seasonal coronaviruses and the fact that previous pandemic influenza viruses have become endemic, it is likely that we will continue to have SARS-CoV-2 transmission.”

Petrie and colleagues analyzed 1,004 seasonal coronavirus infections in 3,418 patients in a cohort of households with children receiving primary care from Michigan Medicine. Of these patients, 40% have been followed for 3 years or more. Patients’ households were screened annually for seasonal coronavirus, and serum tests were performed for SARS-CoV-1 and SARS-CoV-2 spike proteins.

Josh G. Petrie

Of the 1,004 seasonal coronavirus infections, 30% were reinfections of any type of coronavirus, the researchers reported. The number of coronavirus infections ranged from one to 13 per patient.

The levels of binding antibodies to seasonal coronavirus were high, increased little after infection, and were consistent over time, according to the study. The pre-infection antibody levels had no significant influence on the likelihood of infection.

According to Petrie, the limitation of the study is that it cannot determine whether antibodies bound to coronavirus proteins have an impact on virus replication.

“While our findings on seasonal coronavirus reinfections could provide clues as to how SARS-CoV-2 will behave in the future, it will be important to continue to monitor the virus itself and how it behaves if the population is immunized through vaccination and infection increases. ” he said.

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