HealthDay News – Apolipoprotein E4 (ApoE4) genotype, anxiety, and lower hippocampal (HV) and entorhinal cortex volumes (ERV) are at an increased rate of progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD), according to study connected slated for presentation at the annual meeting of the Radiological Society of North America, which will be practically November 29 through December 5.
Jenny L. Uber of the Medical University of South Carolina at Charleston and colleagues studied the effect of anxiety and depression on progression from MCI to AD in a population of 339 patients (mean age 72 years) with a baseline diagnosis of MCI. Of these patients, 72 and 267 developed into AD and remained stable.
The researchers found that there was no difference in age, gender, or years of education in MCI patients with and without AD progression. Significantly lower normalized HV and ERV, higher frequency of the ApoE4 allele, and higher maximal levels of anxiety and depression were observed in patients who progressed to AD. An increased rate of progression from MCI to AD was observed in association with the presence of ApoE4, higher levels of anxiety, and lower HV and ERV.
“We need to better understand the relationship between anxiety disorders and cognitive decline,” a co-author said in a statement. “If in the future we could find that anxiety is actually causing progression, we should look more aggressively for anxiety disorders in the elderly.”
Alzheimer’s Disease and Dementia-Anxiety-Depression