Metabolic

Prophylaxis in opposition to COVID-19 with a novel beta-glucan dietary complement from Japan

(Ed .: Disclaimer: The following press release is made available to you under an agreement with Mediawire. PTI assumes no editorial responsibility for it.) Abilities to combat SARS-CoV2 through immune boosting and blood sugar and cholesterol balancing, published in leading Tokyo journals January 5, 2021: A unique beta-glucan dietary supplement (Nichi Glucan) from Japan that boosts the immune system has been suggested as a possible strategy to overcome the cytokine storm that is causing COVID-19 deaths up to a certain vaccine with a reasonable value The duration of the effectiveness of prevention is generally available to the entire world population, or a drug is being developed to combat this pandemic, especially for the elderly and people with comorbidities. Recently, its potential for preventing COVID-19 complications by balancing blood sugar levels was published in the Journal of Diabetes and Metabolic Disorders (https://doi.org/10.1007/s40200-020-00664-4) and that it is for the prevention of COVID- 19 related blood clotting problems in the journal Thrombosis (https://doi.org/10.1186/s12959-020-00239-6). Because of these capabilities of nichi-glucan, which is produced by the AFO-202 strain of Black Yeast Aureobasidium pullulans, the authors recommend clinical trials in COVID-19 patients to validate that it could serve as a vaccine adjuvant. One in 11 Indian people is prone to diabetes and it is alarming to know that 73% of COVID-19 deaths in India are related to comorbidities such as diabetes, high blood pressure, cardiovascular and respiratory diseases, according to studies. Nichi Glucan (www.nichiglucan.com) possesses both immune-boosting abilities to fight viral infections and immunomodulating abilities to counterbalance the overwhelming immune response that has been documented in previous studies. The scientific evidence available suggests that Nichi Glucan could benefit COVID-19 patients, especially high-risk patients, Dr. Nobunao Ikewaki of Kyushu University of Health and Social Affairs, who has conducted extensive research on beta-glucans, citing his publication in Frontiers in Immunology (https://www.frontiersin.org/articles/10.3389/fimmu.2020.01548/full ). Beta-glucans in lifestyle conditions: While previous pilot studies on Nichi Glucan reported its effectiveness in balancing blood sugar, HbA1C (https://doi.org/10.1155/2012/895370) and cholesterol levels (https://doi.org/) . 10.3109 / 19390211.2013.859211), a recent study in Japan reports that prophylactic or preventive potential may be in store, as well-controlled fasting plasma glucose is reported with a significant reduction in the death rate in COVID-19 patients. The metabolic pathway effects of this dietary supplement should be beneficial in Asian populations with high incidence of diabetes. Some of the proposed mechanisms by which Nichi Glucan helps with metabolic aspects of COVID-19 include delaying gastric emptying, which causes glucose to be slowly absorbed. Flattening of the plasma glucose reaction curve, which lowers the postprandial glucose and insulin reactions, increases the feeling of satiety, improves insulin sensitivity and, via receptors such as Dectin-1 (https://doi.org/), acts on the PI3K / Akt signaling pathway, which at Diabetes is involved. 10.1007 / s40200-020-00664-4). Beneficial effects from blood coagulation systems: Caucasian, African-American and Hispanic people who are at high risk of coagulopathy or a disorder of the blood clotting system are at risk of damage to blood vessels and myocardium, which cause abnormal blood clotting and lead to stroke when COVID- 19 is positive and organ damage increases. Because of the beta-glucan potentials of direct antiplatelet, antioxidant, anticoagulant and antithrombotic effects, the disorders of the coagulation parameters such as the improvement in platelet aggregation and the increase in thrombin levels can be reversed and the effects of the cytokine storm can be reduced, thereby restoring the feedback control mechanisms of thrombin generation through antithrombin III and the improvement of immune function through anti-inflammatory measures (https://doi.org/10.1186/s12959-020-00239-6), Nichi Glucan has strategic capabilities to prevent these complications of COVID- related to the coagulation cascade 19. Immune Boost in COVID-19 and Cancer: Nichi Glucan, which boosts protective immune factors such as cytotoxic T cells and immunoglobulins while controlling those that lead to hyperinflammation including IL6, apart from the immune modulation by sFas and Tr eg cells, has been described in detail in an article a compendium of extensive studies that have been carried out in Japan (https://doi.org/10.3389/fimmu.2020.01548). Based on Immune Boost for Natural Killer (NK) Cells and Their Potential to Fight Bacterial, Viral and Cancer Infections, studied in healthy people, elderly healthy volunteers, and cancer patients, and presented in Japanese Gastroenterology, Nutrition, and Nutrition Societies Dietetics have been conducted by clinicians and scientists at Kochi University, Japan, clinical trials in COVID-19 are planned. Nichi-Glucan for Intestinal Dysbiosis: Dysbiosis or changes in gut microbiota composition have been reported in children with Autism Spectrum Disease (ASD), with changes in gut microbiota affecting the risk of ASD by affecting the immune system and metabolism. Because β-glucans act as prebiotic fiber, thereby modulating the human gut microbiota, a clinical study is being considered to investigate their potential benefits in children with autism and ASD. Nichi-Glucan in Animal Welfare: As animals and birds become increasingly important as zoonotic reservoirs of human disease, the effects of this beta-glucan dietary supplement become important in fighting infections in animals. Nichi Glucan has been shown to be effective against infections such as leishmaniasis, Gumbaro’s disease, malaria, etc. by improving immunity (https://doi.org/10.3347/kjp.2009.47.4.345) and being an effective vaccine adjuvant against Poultry has proven Avian Influenza A H5N1 and H5N2 (J Microbiol Biotechnol. 2011 Apr; 21 (4): 405-11) leads to better livestock growth (https://doi.org/10.1292/jvms.10-0029 ). Nichi Glucan, a globally unique glucan (BRMG), whose unique advantage is the high purity excreted by the black yeast as exopolysaccharide, may not require cumbersome extraction or purification processes to impair purity and thus functionality. More importantly, Nichi Glucan is water soluble and easy to mix with any food. It’s made in a GMP-certified factory on the banks of the Niyodo River in Kochi Prefecture, Japan. Nichi Glucan was approved as a food additive by the Japanese government in 1996. After passing all safety tests according to Japanese standards, according to the manufacturer, it is suitable for consumption by people of all ages. According to GN Corporation, Japan, the only global exporters (www.gncorporation.com), improvised versions of the Nichi Glucan are in the pipeline, with several patents in the pipeline. In India it is available from Amazon (https://www.amazon.in/Nichi-Glucan-Product-Healthy-Building/dp/B08DFDX2HQ). Disclaimer: Nichi Glucan is a dietary supplement. It is not a drug, or a cure, or a cure for any disease. Those who are on medication should consult their doctor before starting Nichi Glucan. The nutritional and ingredient details can be found at www.nichiglucan.com. Contacts: R.Senthil kumar nichiglucan@nichimail.jp Nichi Glucan, food supplement from Japan, now available from Amazon in India (https://www.amazon.in/Nichi) -Glucan-Produkt-Gesundes-Bauen / dp / B08DFDX2HQ) PWR PWR

Disclaimer: – This story was not edited by Outlook staff and is automatically generated from news agency feeds. Source: PTI

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