Metabolic

Postbiotics … an rising pattern in useful meals and drinks? In dialog with ADM

Probiotics are live microorganisms that provide health benefits, and prebiotics are food for probiotics (often fibers that are selectively used by host microorganisms). What are postbiotics?

There is not yet an official definition * (references to postbiotics appear more frequently in the scientific literature from around 2014) and the average consumer is probably not enthusiastic about the term right now. However, postbiotics are sometimes described as “waste” or byproducts of fermentation and can include metabolites such as short chain fatty acids, proteins and peptides and / or discards from beneficial microorganisms. Or they could be a heat-treated or “inactivated” probiotic.

“HT-BPL1 does not contain live microorganisms and is much more resistant to heat.”If you

ADM has invested heavily in probiotic strains such as BPL-1 (human clinical studies suggest that visceral fat and abdominal girth can be reduced).

However, interest in the “postbiotic” heat treated version (HT-BPL1), which can be used in a wider range of food and beverage applications, appears to be growing. Despite her “inactivated” status, Dr. Janice Rueda, VP, Nutritional Business Development, told FoodNavigator-USA.

“Our HT-BPL1 postbiotic can deliver Similar benefits for a load that is no longer alive[ADM has one human clinical study​​ on HT-BPL1 and more in the pipeline]. Postbiotics maintain their stability under harsh processing conditions so they can be incorporated into a wide variety of food and beverage applications that would otherwise be unsuitable for probiotic containment. We have incorporated it into a wide variety of products because it is very easy to use.

“HT-BPL1 does not contain any living microorganisms and is much more heat resistant. It is therefore ideal for products such as confectionery, snacks or baked goods, as well as for beverage applications that can be exposed to harsh thermal processing conditions. ”

WHAT ARE PROBIOTICS? According to the World Health Organization, probiotics are “living microorganisms which, when given in appropriate quantities, can provide health benefits to the host”.

When you think of probiotics, you need to think of the genus, species, and strain (and no two strains are alike), says the International Probiotics Association. For example, for Lactobacillus rhamnosus GG (often referred to as LGG), the genus is Lactobacillus, the species is Rhamnosus, and the phylum is GG.

WHAT ARE PREBIOTICS? According to the International Scientific Association for Probiotics and Prebiotics (ISAPP), a prebiotic is “a substrate that is selectively used by host microorganisms that provide health benefits.”

WHAT ARE POSTBIOTICS? There is no formal definition * yet, but according to a recent article in the journal Nutrients: “Postbiotics include any substance that is released or produced by the metabolic activity of the microorganism and that has a beneficial effect, directly or indirectly, on the host. ”

image: @ GettyImages-Tero-Vesalainen

How does HT-BPL-1 work?If you

She added, “There isn’t a really solid, agreed-upon definition of postbiotics other than that they’re not live, but which is really exciting[to research] What are the mechanisms of action? Is it the cells themselves, the components of the cell walls, that have the effect? Is it the polysaccharides in these cell walls? Is it metabolites or other compounds? “

In the case of HT-BPL-1 – a self-determined GRAS – she said, “We understand this mechanistic function. It is associated with lipoteichoic acid (LTA), a component of the cell wall that interacts in a specific signaling pathway of the cells. This was a really exciting thing that we should understand better as we now know what goal to start honing in via developing ingredient combinations that can enhance this effect. “

Could HT-BPL1 “improve overall populations of the microbiome” and also be called a prebiotic?

“It is possible and likely that HT-BPL1 has prebiotic activity, but we have not yet done the research to determine this,” said Dr. Rueda.

Consumers and PostbioticsIf you

How do consumers feel about postbiotics?

Currently, most U.S. consumers are unfamiliar with the term, although that is likely to change over time as more products hit the market (an example is Cargills EpicorYeast fermentate marketed as a postbiotic, predicted June Lin, global VP, marketing, health & wellness, at ADM.

“Consumers are looking for benefits, so they look for terms like digestive health support or whatever. Then they can turn the pack over, examine the ingredients, and research online. Here you can find out about the differences between pre-, pro- or postbiotics. “

Probiotics: What we are currently seeing from formulators is, “How can we get a message about immune health into our products?”If you

ADM’s portfolio for probiotics includes products with a wide variety of benefits, from skin health to digestive health, immune health, oral health to metabolic health, said Dr. Rueda. However, immunity is definitely a top priority for many customers right now, she said.

“What we are currently seeing from formulators is how we can bring an immune health message into our products. And we have so many tools in the toolbox to help them develop that story, from prebiotics and probiotics to botanicals . ” If you

Beyond bowel movements to the microbiome and healthIf you

According to Mintel, 2,000 new products containing probiotics have been launched in the United States in the past five years, Lin said.

ADM Janice RuedaDr. Janice Rueda: “What we are currently seeing from formulators is: ‘How can we get a message about immune health into our products?'”

Within that set, the main claims are “probiotic / contains probiotics”, digestive health, and immune system health, she said. “However, in the past two years we’ve seen an increase in demands for joint, brain and weight management.”

And as messaging shifts from a narrow focus on bowel movements to something more holistic, consumers think differently about gut health. She said, “Consumers’ understanding of the microbiome and the role of prebiotics, probiotics and postbiotics has changed significantly in recent years.

“Consumers have greater awareness and understanding of the fundamental role of the gut microbiome in relation to individual aspects of health, such as metabolic health, immune function, and the effects it has on overall emotional well-being.”

When buying a probiotic, however, “more than half the consumers[still] Primarily looking for digestive health benefits with a little less looking for probiotics for general health and wellness purposes, ”she explained.

When it comes to preferred delivery vehicles, “consumers are looking for convenient options for probiotic consumption through foods and beverages that do little to change their consumption habits and routines,” she said.

“Many consumers consume foods and beverages with probiotic benefits to support a healthy microbiome. Our research shows that 59% of these consumers use functional foods; 57% use dietary supplements, followed by 51% with functional beverages. ” If you

* There is currently a consensus declaration on the definition and scope of postbiotics to be createdFrom the International Scientific Association for Probiotics and Prebiotics (ISAPP).

From pre-clinical work to clinical studies on humansIf you

How does ADM identify potentially promising probiotics and postbiotics before conducting human clinical trials?

ADM – the acquired Biopolis, A Spain-based microbial technology provider, in 2017; and UK based Probiotics International Limited (protein) In 2018 – uses multiple preclinical models and ‘omics’ technologies, including genomics, transcriptomics, and metabolomics, to characterize the interactions of certain nutrients and ingredients on host microbiome populations, explained Dr. Rueda.

“The C. elegans[a small soil worm or nematode] The model plays a central role in our screening program and has several properties that make it ideal for this purpose: it has a short and reproducible life; it is easy to cultivate; and its genome has been fully sequenced. An example is a published paperDescription of the effects of HT-BPL1 on fat reduction in the C. elegans model in the matrix context of powdered infant formula.

“With this pre-clinical mechanistic understanding, we can then begin human clinical trials to demonstrate the safety and effectiveness of these unique products.”

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