Infectious Disease

Non-AIDS comorbidities are extra frequent in girls with HIV

February 02, 2021

2 min read

Source / information

Published by:

Disclosure:
Ofotokun does not report any relevant financial information. In the study you will find all relevant financial information from all other authors.

ADD SUBJECT TO EMAIL ALARMS

Receive an email when new articles are published

Please enter your email address to receive an email when new articles are published . “data-action =” subscribe “> subscribe

We could not process your request. Please try again later. If you continue to have this problem, please contact customerservice@slackinc.com.

Back to Healio

Non-AIDS comorbidities are more common in women with HIV than in HIV-seronegative women, with the most dramatic difference occurring in women under the age of 25, according to one study.

In the age of combined ART, age-related non-AIDS comorbidities (NACM) such as cardiovascular, kidney, liver and bone diseases are increasingly responsible for morbidity and mortality as the life expectancy of people with HIV (PWH) approaches that of the general population among this population said Ighovwerha Ofotokun, MD, MSc, Professor of Medicine in the Department of Infectious Diseases at Emory University School of Medicine.

Ighovwerha Ofotokun,

“Women with HIV are historically underrepresented in PWH clinical cohorts studying the burden of multimorbidity,” Ofotokun told Healio. “Using the Interagency HIV Study for Women (WIHS), we recently showed in a cross-sectional analysis that the exposure to widespread NACM was higher in women with HIV overall and in certain age groups than in women without HIV.”

Ofotokun, together with Lauren F. Collins, MD, and colleagues studied the effects of HIV serostatus and age on NACM exposure in WIHS participants to better understand the longitudinal effects of chronic HIV in aging women. According to the study, women living with HIV (WLWH) and HIV-seronegative participants were included in the study until and after 2009, when more than 80% of the WLWH used ART. The results were recorded through March 3, 2018.

A total of 3,129 participants participated in the study, 2,239 WLWH and 890 HIV-seronegative women with 36,589 person-years of follow-up. In fully customized analyzes, the study showed that WLWH had a higher NACM rate compared to HIV-seronegative women (incidence rate) [IRR] = 1.36, 95% CI, 1.02-1.81). In addition, NACM exposure was higher in WLWH compared to HIV-seronegative women in most age groups, and women under 25 years of age had the highest IRR from HIV at 1.48 (95% CI, 1.19-1.84) -Serostatus compared to women in older age groups.

The researcher said NACM exposure was linked to traditional comorbidity risk factors, but not to HIV-specific indices.

“The clinical takeaway message is that the rate of NACM delineation was high for all women in the cohort, but higher for women with HIV, and started in their third decade of life,” Ofotokun said. ‚ÄúThese findings support the need for earlier, more aggressive NACM screening and prevention for young women with HIV and women at risk that could be incorporated into a broader women’s health agenda at reproductive age. To reduce the burden of NACM incidents in this high-risk population, innovative HIV- and women-specific tools for risk assessment of comorbidity and risk reduction are needed, including targeted attention to social determinants of health. “

ADD SUBJECT TO EMAIL ALARMS

Receive an email when new articles are published

Please enter your email address to receive an email when new articles are published . “data-action =” subscribe “> subscribe

We could not process your request. Please try again later. If you continue to have this problem, please contact customerservice@slackinc.com.

Back to Healio

Related Articles