THURSDAY, December 10, 2020 (HealthDay News) – According to a study published online on November 12 in PLOS ONE, kidney disease is the strongest pre-existing factor in hospitalizations for COVID-19.
Matthew T. Oetjens, Ph.D., of the Geisinger Health System in Danville, Pennsylvania, and colleagues used electronic health records to determine clinical phenotypes of the pre-COVID-19 pandemic (12,971 people) related to hospitalization for COVID-19 evaluate.
The researchers found that 1,604 patients were severe coronavirus 2 positive with acute respiratory syndrome and 354 had to be hospitalized. Twenty-one clinical phenotypes in five disease categories fulfilled a phenomenon-wide meaning, including six renal phenotypes (e.g. end-stage kidney disease or chronic kidney disease stage 5: odds ratio) [OR], 11.07), six cardiovascular phenotypes (e.g. heart failure: OR, 3.8), five phenotypes of the respiratory tract (e.g. chronic airway obstruction: OR, 2.54) and three metabolic phenotypes (e.g. type 2 diabetes: OR, 1.80). When defining chronic kidney disease based on the estimated glomerular filtration rate, there was a similarly high risk of hospitalization with pre-existing stage 4 chronic kidney disease (OR, 2.90), stage 5 chronic kidney disease with dialysis (OR, 8.83 ) and a kidney transplant (OR 14.98).
“Our team took a novel approach made possible by our extensive electronic health records, unique demographics and integrated healthcare system,” a co-author said in a statement. “We were able to do this study even though the number of COVID-19 cases was much lower compared to large metropolitan hospitals.”
Abstract / full text