Sleep disorders, including obstructive sleep apnea (OSA) and insomnia, are common in patients hospitalized for COVID-19, but these disorders do not appear to contribute to mortality or severe outcomes associated with the novel coronavirus, according to study results published in the Journal clinical sleep medicine.
The study included 572 adult patients hospitalized for COVID-19 in the University of Michigan hospital system. The study researchers evaluated electronic health records to determine the prevalence of sleep disorders. Diagnostic sleep studies, conducted in 13% of the study population, were conducted either in a laboratory or off-center using Type 3 portable monitors.
The study’s researchers conducted an analysis to assess the association of insomnia with mechanical ventilation requirements, the need for vasopressor treatment, and death.
Approximately 19.8% (n = 113) of the 572 patients hospitalized for COVID-19 had OSA. Only 0.7% (n = 4) of the entire cohort had central sleep apnea, while 11.0% (n = 63) had insomnia. The results showed hypoventilation in 0.9% (n = 5) of hospitalized patients and restless legs syndrome or periodic limb movement disorder (RLS / PLMD) in 3.9% (n = 22) of patients .
While the overall prevalence of sleep disorders in the study population was high, the researchers found no significant association between specific diagnoses of sleep disorders or indices for sleep-related breathing disorders with disease severity in an analysis adjusted for age, gender, body mass index and the results. and races.
The presence of OSA and insomnia was associated with an increased probability of death (OR 1.83; 95% CI 0.89-3.75) and the need for vasopressors (OR 1.86; 95% CI 0.98-3.56) connected. There was no significant association between the presence of OSA, insomnia, or RLS / PLMD and the use of mechanical ventilation, the need for vasopressors, the length of stay, or death.
Limitations of this study included reliance on diagnostic codes to identify sleep disorders and the lack of available data on treatments for sleep disorders in the cohort.
The study’s researchers concluded that “sleep disorders may be relevant to long-term cardiac outcomes because of their contribution to cardiovascular health” in patients with COVID-19, but it remains “an open question whether new sleep disorders will have long-term consequences in these patients will recover from severe COVID-19. “
Goldstein CA, Rizvydeen M, Conroy DA, et al. The prevalence and impact of pre-existing diagnoses of sleep disorders and objective sleep parameters in patients admitted to hospital for COVID-19. J Clin Sleep Med. Published online February 9, 2021. doi: 10.5664 / jcsm.9132