Infectious Disease

Low LDL ranges and excessive triglycerides can point out a danger of dying in hospitalized COVID-19

December 12, 2020

2 min read

Source / information

Source:

Teufel K et al. Abstract 268. Presented at: National Lipid Association Scientific Sessions; 10-12 December 2020 (virtual meeting).

Disclosure:
Teufel does not report any relevant financial information.

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Among patients admitted to hospital with COVID-19, LDL levels below 50 mg / dL and triglycerides above 150 mg / dL were individually associated with increased mortality rates, according to a presentation.

“Previous studies have shown lipid abnormalities in patients with SARS-CoV-2 who were mainly analyzed for total cholesterol. Our study suggests that patients with COVID-19 who have unusually low LDL levels yet elevated TG levels have a higher mortality, ”wrote Dr. Karolyn Teufel, Assistant Professor of Medicine at George Washington University Hospital in Washington, DC, and colleagues in a poster presented at the National Lipid Association’s virtual scientific sessions. “When admitted, these lipid biomarkers can act as independent prognostic markers for patients. In addition, it is unusual to see low LDL and high TG levels in a patient with metabolic syndrome – one would expect such patients to experience elevated LDL levels. “

Hospital beds

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This retrospective analysis included 254 patients hospitalized with COVID-19 (mean age 62 years; 54% men; 70% blacks) who had random lipid measurements during their stay at George Washington University Hospital. The researchers examined the link between lipid biomarkers and mortality in patients hospitalized with COVID-19.

In this hospital, the lower limit of the normal LDL range is 50 mg / dL, the lower limit for HDL is 40 mg / dL and the upper limit for triglycerides is 150 mg / dL.

The researchers observed a higher likelihood of mortality if the direct LDL was below 50 mg / dL at any time during a patient’s hospital stay (OR = 3.73; 95% CI, CI 1.85-7.51).

In an analysis of triglyceride levels and mortality while hospitalized with COVID-19, the researchers found an increased likelihood of death if the maximum triglyceride level was greater than 150 mg / dL during a patient’s stay (OR = 4.32; 95% CI 2.35-7.97).

In addition, an HDL of less than 40 mg / dl showed a trend towards increased mortality, but was not statistically significant.

“The combination of low LDL and high TG levels is particularly worrying,” wrote Teufel and colleagues. “And high TG levels, which are associated with low HDL, although the latter did not reach significance, suggest the presence of a metabolic syndrome at a baseline for our subjects. Our results complement the current literature, which continues to show that both metabolic syndrome and obesity are risk factors for severe COVD-19. “

In other findings, the researchers observed no association between statin use and mortality, with a similar proportion of statin and non-statin users dying (22% versus 22%; P = 0.98).

Also, according to the poster presentation, statin use was not associated with mortality from COVID-19 when analyzed in subsets of patients with LDL above or below 50 mg / dL.

“Future studies would further compare lipid biomarkers on a longer longitudinal time axis as well as multivariate analyzes to examine the role of other conditions and biomarkers associated with these lipid abnormalities in COVID-19 infection,” wrote Teufel and colleagues.

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National Lipid Association

National Lipid Association

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