The casomorphins – breakdown products of casein, a milk protein with opiate-like activity – in beef milk appear to have opposite effects on infant development than those found in human breast milk, but what about A2 cow’s milk?
“One of the main sources of opioid peptides” – ie protein fragments with opiate-like activity – “in the diet of autism patients” are Dairy products. “As I discuss in my video Does A2 milk have a lower risk of autism?, Casein, the most important milk protein, breaks down to casomorphins, which are “viewed as factors involved in etiology” [the cause] and exacerbation of symptoms in food allergy and atopic dermatitis [eczema], Diabetes, schizophrenia, postpartum psychosis, sudden infant death syndrome (SIDS) and autism. According to this opioid excess idea, developing autism involves a genetic predisposition and early exposure to a type of environmental stressor that affects the gut, which can cause more of these casomorphins to leak into the blood and then into the brain, where they are may play a role in the development of autism. However, you don’t know until you put it to the test.
These bovine casomorphins form in the human digestive tract when we drink Milk? Researcher decided Insert tubes into the subjects’ intestines to find out, and in fact, “significant amounts” of casomorphine were found. Get it absorbed but in the bloodstream? Yes, apparently, but the study was in infants who have naturally leaky viscera. Do completely intact casein protein fragments get into the bloodstream after infancy? Yes as you can see in mine at 1:24 Video. Indeed they can receive into the bloodstream into adulthood, uplifting Blood levels for at least eight hours after ingestion.
And those with autism can have a particularly leaky intestine with a significantly higher risk of unusually high intestinal permeability, the to explain why the vast majority of children with autism may have antibodies to wheat and milk proteins in their blood compared to a small minority of children without autism, like you at 1:44 in my. can see Video. And, based on allergy studies, even when infants are strict breastfed, They may still be exposed to beef milk proteins when their mothers drink milk as the beef protein fragments can get into the mother’s blood, then into her breast, and then into her baby’s body. But do the cow proteins also get into the baby’s brain?
People with autism are more likely to Suffer by Leaky Gut, but the “opioid excess theory” is based on the fact that casomorphins not only get into the bloodstream, but also into the central nervous system, which also includes the brain. There is such a thing as the blood brain barrier that helps Cordon from the brain, but when you examine the brain tissue of people with autism, their blood-brain barrier also appears to be leaking. In fact, there has been evidence of the presence of casomorphins in the brains of infants since then Approved. When you think about it, it just makes sense. Presumably, the point of casomorphine opioids is to manipulate babies’ brains into craving for milk and crying out for milk, thereby strengthening the mother-child bond and, similarly, the cow-calf bond. That is supposed to happen. It’s normal and natural. Then why are casomorphins associated with disease? Well, such a bond is natural between a human mother and her human infant, while one between a cow and a baby or a human mother and a calf is not.
As you can see in mine at 3:24 Video, human infants seem more likely to have evidence of higher baseline levels of bovine casomorphins in their blood Suffer from psychomotor delay, which is a measure of the development of muscles, speech, and mental function, but the opposite has been found for human infants’ exposure to human casomorphins, meaning that human casomorphins appeared to be beneficial to humans. Just as bovine casomorphine levels seem to increase in the blood of human babies after being fed cow’s milk, so too does human casomorphine levels in babies after breastfeeding, which is supposed to happen. “The largest basal irHCM [baseline human casomorphins] has been demonstrated in breastfed infants with normal psychomotor development and normal muscle tone. In contrast, basal irBCM increased [baseline bovine casomorphins] was found in [cow’s milk] Infants fed infant formula exhibiting a delay in psychomotor development ”and stiffer muscle tone.
“The explanation of the opposing effects of human and bovine CM [casomorphins] on the psychomotor development and muscle tone of infants were probably due to their species specificity. ”Cow’s milk is good for calves and Breast milk is good for babies. In fact, the structures of bovine casein and human casein are dramatically different, and the bovine and human casomorphins themselves are different molecules, differentiated by two amino acids, resulting in vastly different potency levels. Compared compared to human casomorphine, bovine casomorphine is “highly effective and similar in effect to morphine”.
There can be no difference between two amino acids seem to be like many, but casomorphins are only seven amino acids long. This difference of about 30 percent “probably” Are defined a difference in their biological properties. Both human and bovine CMs [casomorphins]… interact with opioid and serotonin receptors, which are known to be of great importance for the CNS [central nervous system, including the brain] Maturation ”, but bovine casomorphine binds more strongly to these receptors, so it has a stronger effect. Not only can this help explain why the breasts are best, but why the psychomotor delay associated with higher levels of bovine casomorphins in the blood supports this concept that cow casomorphins play a role a disease like autism.
For this reason, beef casomorphins were made called “The devil in the milk” but are they? educated from all cow’s milk? What about “A2” milk? The A2 Corporation Points There are several varieties of casein: some cows produce milk with a type of casein called A1, while other cows produce milk with A2 casein. A2 differs from A1 in only one amino acid, but one that is strategically placed so that A1 casein breaks down into casomorphine, which acts like morphine and “is involved in changes in the digestive system, the immune system and brain development”. Supposedly, A2 milk doesn’t do the same. As you can see in mine at 6:18 am Videoif you put A1 milk with some digestive enzymes in a test tube, the A1 casein breaks down in casomorphine. But because of this one amino acid difference, the A2 casein is broken down at a different point and no casomorphine is formed.
This study, however used Pig or cow digestive enzymes cheaper and easier to buy for laboratory testing. Human digestive juices are different, so what? happens a pig or cow’s stomach doesn’t necessarily have to be what happens in the human digestive tract.
When the experiment to break down A1 versus A2 was finally performed with human enzymes, what was discovered? Human gastric and intestinal juices were collected, and the devil was found in both. The opioid casomorphine was made from both A1 milk and A2 milk. Therefore, A2 milk may be better for pigs or cows, but not necessarily for humans.
This article discusses the second video in a six-part series on the role of gluten and dairy-free diets in the treatment of autism. If you missed the first video, see Cow’s Milk Autism and Casein.
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I previously touched A1 vs. A2 milk in Does casein in milk cause type 1 diabetes? and Does beef insulin in milk cause type 1 diabetes?.
In health,
Michael Greger, MD
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