Infectious Disease

Hospital mortality is considerably larger with COVID-19 than with flu

February 10, 2021

2 min read

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Verma reports receiving personal fees from Ontario Health. In the study you will find all relevant financial information from all other authors.

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Patients hospitalized with COVID-19 were almost 3.5 times more likely to die than influenza patients, according to a study published in the Canadian Medical Association Journal.

“We can now definitely say that COVID-19 is much more severe than seasonal influenza.” Amol A. Verma, MD, MPhil, BSc, A general practitioner resident at St. Michael Hospital, Unity Health Toronto and the University of Toronto said in a press release. “Patients admitted to hospital in Ontario with COVID-19 were 3.5 times more likely to die, 1.5 times more intensive care unit use, and 1.5 times longer hospital stays than patients who were with influenza were recorded. “

Reference: Verma A et al., CMAJ. 2021; doi: 10.1503 / cmaj.202795.

Verma and colleagues conducted a retrospective cohort study using information from seven hospitals in Toronto and Ontario. They assessed adults enrolled in the intensive care unit between November 1, 2019 and June 30, 2020.

A total of 783 influenza recordings and 1,027 COVID-19 recordings were included in the study. The researchers found that these recordings accounted for 23.5% of all COVID-19 hospital admissions in Ontario during the study period.

Patients under the age of 50 accounted for 21.2% of all COVID-19 admissions and 24% of all intensive care admissions for COVID-19.

Researchers found that patients admitted with COVID-19 had significantly higher hospital mortality compared to patients with influenza (19.9% ​​vs 6.1%; adjusted RR) [aRR] = 3.46; 95% CI, 2.56-4.68).

They also found that patients with COVID-19 had a significantly higher level of use in the intensive care unit compared to patients with influenza (26.4% versus 18%; aRR = 1.5; 95% CI, 1.25-1, 80).

In addition, patients with COVID-19 had longer hospital stays, with a median of 8.7 days compared to 4.8 days for patients with influenza (aRR = 1.45; 95% CI, 1.25-1.69).

According to the researchers, patients with COVID-19 were more likely to receive invasive ventilation than those with influenza (18.5% versus 9.3%; P = 0.001), but less likely to have bronchoscopy (2% versus 5.6%) ; P = 0.005).

The readmission rate after 30 days did not differ significantly between patients admitted with COVID-19 and patients with influenza (aRR = 0.98; 95% CI, 0.70-1.39).

“These differences can be compounded by poor immunity to the novel coronavirus compared to seasonal influenza resulting from previous infections and vaccinations,” Verma said in the press release. “Hopefully, the severity of COVID-19 will decrease over time as people are vaccinated against the virus and more effective treatments are identified. Unfortunately, there is also a possibility that variants of the virus are even more serious. “

References:

Press release

Verma A. et al., CMAJ. 2021; doi: 10.1503 / cmaj.202795.

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