One food can potentially combat all four of the alleged causal factors in autism: synaptic dysfunction, oxidative stress, mitochondrial dysfunction, and neuroinflammation.
Harvard neurologist Martha Herbert gave a keynote address at an autism conference said“I think we need to do research like we know this is an emergency.” Already up to 1.5 percent of American children to have Autism and it appears be on the rise. What about the dramatic effects of the fever? “Dramatic relief of autistic behavior through infectious fever continues To seduce parents and practitioners ”and indeed from a research perspective:“ What could be more revealing than a frequent event that practically “normalizes” autistic behavior for a certain period of time? ” But, “[t]There is so much going on here during the fever … Where do I start? “
Once it became clear that autism can be a cause dwell In the synapses – the “soul of the brain”, the nerve-nerve connections through which information is transmitted – attention was focused on heat shock proteins that are released by the brain during a fever. You can improve synaptic transmission and therefore may be able to improve the connectivity of the brain over long distances, which is impaired in autism. One compound, sulforaphane, upregulates these heat shock proteins so you can potentially get the benefits without a fever. Which pharmaceutical company does it? What do I ask in the pharmacy? You do not do that. As I discuss in my video Fight Autism Encephalitis With FoodAll you have to do is look at the product section in your local market.
Sulforaphane isn’t made in a chemical plant – it is made from a plant. Sulforaphane is made from broccoli, kale, cabbage, cabbage, and cauliflower – in other words, cruciferous vegetables. If we give broccoli to people with autism, it may improve the situation increase the heat shock proteins.
But as you can see in mine at 1:57 Video, synaptic dysfunction is not the only cause of autism. There is also oxidative stress. “The brain is particularly susceptible to oxidative stress” because many free radicals are forged in the brain, which has only a few “antioxidant defense capacities”. Indeed, there is “a long history of studies showing that ASD [autism] is associated with oxidative stress and decreased antioxidant capacity. “Nrf2 levels are almost cut in half, whatever the case triggers our body’s antioxidant response. Nrf2? What’s this? It is “considered being a major regulator “of our body’s response to environmental stressors. If only there was a way to boost Nrf2 with food. Well there is.
Sulforaphane happens to be the “most potent naturally occurring inducer” of Nrf2 on the planet. Under any type of stress – oxidative stress, inflammatory stress – Nrf2 triggers our antioxidant response elements and activates all kinds of cell protecting genes that balance and detoxify the free radicals and facilitate protein and DNA repair. So if we give some broccoli to people with autism, it may also improve the situation by triggering Nrf2 which activates these antioxidant response elements.
There is also mitochondrial dysfunction. Children with autism are more likely to do so To suffer of dysfunctional mitochondria, the small power plants in our cells in which the metabolism takes place. If only there was something to eat that could improve mitochondrial function. And there is, “A diet that is effectively cruciferous retunes our metabolism through… restoring metabolic homeostasis, or metabolic balance. Power plants for our cell power plants.
As you can see in mine at 3:58 Videocan not only sulforaphane Boost The gene expression of heat shock proteins has increased six-fold within six hours, but it can also double the mass of mitochondria in human cells that grow in a Petri dish. So if we give some broccoli to people with autism, it may also improve the situation by alleviating part of this mitochondrial dysfunction that creates even more free radicals.
Can we try to give these kids broccoli yet?
Before we do that, there is one final factor. Neuroinflammation – inflammation of the brain – is another causal factor in autism. When you do the autopsy look In the brain tissue of people with autism, you can see inflammation throughout the white matter. If you tap the spine, you’ll find up to 200 times as many inflammatory mediators as interferon bathing your brain. What is causing all of this inflammation?
Well, the main regulator of the inflammatory cascade is a protein called NF-kappa-beta, which induced Inflammation. When it is overexpressed, like in autism, it can to lead to chronic or excessive inflammation. If only there was one meal …
“Really?” Does broccoli do that too? Yes! In fact, the main anti-inflammatory mechanism for is sulforaphane inhibiting NF-Kappa-Beta.
This completes the picture. Give broccoli to someone with autism and heat shock proteins will be released to aid synaptic transmission. Nrf2 is activated to eradicate the free radicals, mitochondrial function is restored and we suppress the inflammation caused by NF-kappa-beta. One food counteracts all four alleged causal factors in autism. That’s one of the differences between food and drugs. Drugs tend to have single effects. But autism spectrum disorder is multifactorial, so it’s no wonder there aren’t any drugs that do job. But “strategies with multifunctional secondary plant substances” such as sulforaphane or even better, the entire plants themselves are “very attractive” … theoretically. But you don’t know until you put it to the test that I describe in my video Best foods for autism. You can also check: Flashback Friday: The Best Foods to Fight Autism and Brain Inflammation.
Dramatic Relief from Autistic Behavior During a Fever? If you missed it, check out my last video. Fever Benefits For Autism In One Food.
For more information on autism, visit:
What else can Broccoli’s magic do?
Michael Greger, MD
PS: If you haven’t already, you can subscribe to my free videos Here and check out my live presentations: