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Distant electrical neuromodulation (REN) is a safe and effective treatment option for the acute management of migraines in adolescents. This is based on study results presented at the American Academy of Neurology (AAN) annual virtual meeting 2021 from April 17-22, 2021.
Conditioned pain modulation is an endogenous analgesic mechanism that can be induced by REN, an acute treatment for migraines in adults approved by the US Food and Drug Administration. The aim of the current study was to determine the safety and effectiveness of REN in adolescents with migraines.
This open-label, multicenter study included 60 adolescents with migraines between the ages of 12 and 17 years. All participants went through a 4-week break-in period during which headaches were recorded. Eligible participants continued their 8-week treatment phase.
A total of 39 patients underwent test treatment with REN; The study researchers recorded their pain severity and associated symptoms at the start of treatment, 2 after treatment, and 24 hours after treatment.
Two hours after treatment, they showed pain relief in 28 of 39 (71%) patients, and freedom from pain was achieved in 14 of 39 (35%) patients. In more than 40% of the patients, nausea, photophobia and phonophobia disappeared. Functionality improved in 69% of patients.
Consistency analyzes across multiple seizures showed that two-thirds of patients experienced pain relief in 50% or more of their treated seizures and one-third experienced pain-free reactions.
Treatment with REN was safe. A single (2%) device-related adverse event of transient arm pain was reported in 45 patients who used the device at least once.
“REN provides clinically meaningful relief from migraine pain and related symptoms and offers a safe and effective solution [nonpharmacological] Alternative to acute treatment in adolescents, ”concluded the study researchers.
Hershey A, Lin T, Gruper Y, Berenson F. Electrical remote neuromodulation for the acute treatment of migraines in adolescents. Presented at: American Academy of Neurology’s Annual Virtual Meeting 2021; April 17-22, 2021. Abstract P10.028.