Infectious Disease

Diagnosing a mood disorder increases the risk of COVID-19 mortality in hospitalized patients

April 09, 2021

1 min read

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Castro does not report any relevant financial information. In the study you will find all relevant financial information from all other authors.

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According to a retrospective cohort study published in the American Journal of Psychiatry, hospitalized patients with a history of mood disorders were at increased risk for higher COVID-19 morbidity and mortality.

“Growing evidence that SARS-CoV-2 can directly or indirectly affect brain function is also increasing concerns about the interaction between pre-existing disorders in which the [central nervous system]including mood disorders and undesirable outcomes ” Victor M. Castro, MS, from the Department of Psychiatry at Harvard Medical School, and colleagues wrote. “If [central nervous system] Traits represent a direct result of infection, a secondary effect of immune activation and cytokine release syndrome, or a specific mechanism secondary to COVID-19. They can make the treatment of acutely ill patients difficult, especially in resource-constrained environments. “

Reference: Castro VM et al. Am J Psychiatry. 2021; doi: 10.1176 / appi.ajp.2020.20060842.

Castro and colleagues wanted to investigate the association between a diagnosis of a previous mood disorder and hospital outcomes in 2,988 people, of whom 717 were diagnosed with a previous mood disorder and who were admitted to two academic medical centers and four community hospitals in eastern Massachusetts with COVID-19 15. February 2020 and May 24, 2020. They created the retrospective cohort using the institutes’ electronic health records and used regression models to assess the associations between history of mood disorders and hospital mortality and hospital discharge in all hospital patients tested positive for SARS-CoV-2.

The results of Cox regression models adjusted for age, gender and hospital location showed that the presence of a mood disorder before admission was associated with a higher risk of in-hospital mortality after day 12 of hospital (fully adjusted HR = 1.54; 95 % CI, 1.054-2.25). Researchers also found that a diagnosis of a mood disorder was associated with an increased risk of being discharged to a skilled nursing home or other rehabilitation facility instead of home (fully adjusted OR = 1.504; 95% CI, 1.132-1.999).

“Psychiatric comorbidities, and particularly mood disorders, must be carefully considered in hospitalized COVID-19 patients,” wrote Castro and colleagues. “The mechanism by which a pre-existing mood disorder can affect the course and outcome of a hospital should be further explored in large clinical cohorts as well as at the neurobiological level.”

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