Infectious Disease

Deadly COVID-19 Outcomes Associated to CVD, Threat Components No matter Age

December 31, 2020

1 min read

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Bae does not report any relevant financial information. In the study you will find all relevant financial information from all other authors.

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According to a meta-analysis, fatal results in COVID-19 have been linked to patients with CVD and risk factors such as high blood pressure and diabetes in all age groups.

“The presence of an underlying CVD increases both the severity of the primary respiratory disease and the risk of developing further complications.” Sunga Bae, MD, from the Department of Cardiology at Korea University Anam Hospital in Seoul, South Korea, and colleagues wrote. “The main risk factors for mortality in patients with COVID-19 have been reported to include age greater than 60 years, male gender, and the presence of comorbidities.”

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For the meta-analysis, the researchers evaluated 51 studies with 48,317 patients (mean age 56 years; 58% men) with COVID-19 by June. In the included studies, patients were examined in hospital. The researchers stratified the comorbid disease prevalence rates and clinical outcomes according to the patient’s mean age.

The primary outcome was a composite fatal outcome from severe COVID-19 or death.

The researchers observed a significantly higher relative risk of developing severe COVID-19 infection or death in patients with risk factors for CVD such as high blood pressure (OR = 2.5; 95% CI, 2.15-2.9) or diabetes (OR = 2.25; 95% CI, 1.89) -2.69) and in patients with CVD (OR = 3.11; 95% CI, 2.55-3.79). Younger patients (under 50 years of age) showed a lower prevalence of high blood pressure, diabetes, and CVD compared to older patients (60 years of age or older), but the relative risk of fatal consequences in younger patients was higher.

According to the researchers, the exact reason why younger patients with CVD or risk factors for CVD were at higher risk for poor clinical outcomes compared to older patients is unknown.

“Although young patients had a lower prevalence of cardiovascular comorbidities compared to older patients, their relative risk of developing fatal consequences was higher than that of older patients,” the researchers wrote. “In the case of patients with COVID-19, we must pay special attention to young patients with cardiovascular morbidities and the elderly.”

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