Infectious Disease

COVID-19 vaccination seems to be “protected” for pregnant ladies

February 11, 2021

3 min read

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Adhikari does not report any relevant financial information.


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More than 9,300 women with COVID-19 have completed pregnancies in the United States, according to the CDC.

Research has shown that pregnancy increases the risk of developing severe COVID-19 illness and that COVID-19 is related to ICU admission during pregnancy and premature delivery.

Adhikari quote

In a recent editorial in JAMA, Emily H. Adhikari, MD, and Catherine Y. Spong, MD, The University of Texas’ Southwestern Medical Center at Dallas wrote that “Doctors can empower women to make informed decisions” by getting vaccinated against COVID-19.

“With an understanding of the important practice of vaccination in pregnancy, the use of other vaccines during pregnancy, the effectiveness and safety of COVID-19 [messenger RNA (mRNA)] With vaccines in non-pregnant populations and their immune response mechanism, clinicians can demonstrate the benefits of preventing COVID-19 disease, as well as the undefined but potentially limited risk to the fetus and potential benefit to the newborn, “they wrote.

“As part of the discussion,” the researchers continued, “empathetic clinicians should acknowledge the limited evidence available and the tension about the potential benefits of vaccination, weighed against the potential risks, real or theoretical, and be willing to To dispel myths. ” . ”

Healio spoke to Adhikari about vaccinating pregnant women against COVID-19.

Q: Is it safe for pregnant Get women vaccinated against COVID-19?

ON: Based on our experience over the past few months, it seems safe for pregnant women to be vaccinated against COVID-19. However, we need published, peer-reviewed data to confirm this.

The important thing is that the context is important. The decision not to receive the vaccine has an impact as the virus spreads rapidly and different strains emerge. COVID-19 causes significant illness that requires hospitalization in 5% to 6% of all pregnant women infected with SARS-CoV-2. Pregnant women with severe or critical COVID-19 illness are at an increased risk of premature birth and loss of pregnancy. This risk is primarily due to a maternal illness and not a direct impact on the fetus. Pregnant women may also be at greater risk of serious illness and death from COVID-19 than non-pregnant women of similar ages. Therefore, preventing infection is important for both mother and fetus. The best way to prevent COVID-19 infection is to get vaccinated.

Q: What does the CDC says, and what does WHO say?

ON: The CDC recognizes that limited data are currently available, including animal development and reproductive toxicity studies (DART). No safety concerns were identified from these data. They say pregnant people may be able to opt for a vaccination if they belong to a prioritized group and that pregnant people with COVID-19 are at increased risk of serious illness.

Q: What was the most recent revision of the WHO?

ON: The WHO statement published on January 26th strongly recommended not to vaccinate pregnant women with the Moderna mRNA vaccine. This statement was not based on new data or published information. As a result, the WHO revised its statement on January 29 to use more permissive language. WHO now says that while the data are limited, based on our knowledge of this type of vaccine, we have no particular reason to believe that there will be specific risks that would outweigh the benefits of vaccination for pregnant women.

Q: are Vaccine Makers Test COVID-19 Vaccines In Pregnant Women?

ON: Manufacturers have done some preliminary animal DART studies and additional registration studies are planned. They invite vaccinated pregnant women to enroll for their vaccine-specific registration studies. In addition, vaccinated pregnant women can be tracked via the CDC’s V-safe smartphone app, which collects data after vaccination. Over time, a placebo-controlled vaccine study in pregnant patients becomes less likely. However, observational data is published by local institutions (including ours) who follow vaccinated pregnant women over time.

Q: Is there any data in advance of the inclusion of pregnant women in studies to suggest that the vaccines should be considered safe for use in pregnant women?

ON: Vaccinations during pregnancy are common to prevent maternal and child morbidity from other infectious diseases. Influenza immunization during pregnancy reduces influenza-like illness in the mother by 19%, low birth weight by 15%, and influenza in children by 30%. Pregnant women who received the pertussis vaccine (Tdap) in the third trimester reduced pertussis in infants by 85% compared to postpartum vaccination.

While new to COVID-19, these mRNA vaccine platforms are not entirely new. Similar mRNA vaccines have been used in clinical trials against other infections such as Zika virus, as well as against various cancers. These mRNA vaccines stimulate an immune response, but they are not infectious, and you cannot get COVID-19 from these vaccines. They don’t integrate into DNA or don’t mutate.

Since the two vaccines manufactured by Pfizer and Moderna were granted emergency approval, more than 10,000 pregnant women have been vaccinated in the US and so far there have been “no red flags,” which is reassuring.

Q: Is One Vaccine Or Vaccine Technology Better Than Another For Pregnant Women?

ON: There is no data to suggest that any type of vaccine is better than another, and since pregnant women were excluded from early clinical trials, we do not differentiate between the two in terms of safety. Both vaccines (Pfizer and Moderna) use the mRNA vaccine platform, and both vaccines appear to be very good at protecting against COVID-19 disease after receiving two doses.


CDC. COVID-19 Data During Pregnancy: Birth and Infant Outcomes. Accessed February 10, 2021.


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