HealthDay News – Circulating metabolites, including amino acids, glycolysis-related metabolites, acute phase response markers, and lipoprotein subfractions, are linked to stroke risk, according to a study published online in Neurology on December 2.
Dina Vojinovic, Ph.D., from the University Hospital in Rotterdam, the Netherlands, and colleagues examined the association between metabolites and stroke risk in seven prospective cohort studies, including 1,791 stroke events in 38,797 participants. Circulating metabolites were measured using nuclear magnetic resonance technology.
The researchers identified 10 significant metabolite associations. Associations with stroke risk have been established for the amino acid histidine (hazard ratio per standard deviation, 0.90), glycolysis-related metabolites pyruvate (hazard ratio per standard deviation, 1.09), acute-phase reaction markers glycoprotein acetyls (hazard ratio per standard deviation, 1.09) and cholesterol in high density lipoprotein 2 and several other lipoprotein particles. A significant association was observed with phenylalanine (hazard ratio per standard deviation, 1.12) and total and free cholesterol in large HDL particles when focusing on an incident ischemic stroke.
“Our analysis provides new insights into how the risk of stroke can be influenced at the molecular level. It also raises new questions, ”Vojinovic said in a statement. “Future studies are needed to further explore the biological mechanisms underlying these metabolite-stroke risk relationships.”
One author gave financial links to Nightingale Health Ltd. known that offers metabolomics profiling. Several of the studies revealed funding from the biopharmaceutical industry.
Summary / full text (subscription or payment required)