Infectious Disease

Actual knowledge trumpet effectiveness of the recombinant zoster vaccine

February 27, 2021

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Sun reports it has received grants from the NIH. In the study you will find all relevant financial information from all other authors.

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Real data reported in clinical infectious diseases showed that the recombinant zoster vaccine was more than 85% effective at preventing herpes zoster.

The recombinant herpes zoster (RZV) vaccine has previously been shown to be more protective and less expensive than live vaccine or no vaccine. Another study showed that herpes zoster-related pain was reduced.

Herpes zoster vaccine graphic

Source: Sun Y et al. Clin Infect Dis. 2021; doi: 10.1093 / cid / ciab121.

“Understanding the effectiveness of RZV in practice outside of clinical trial settings is critical given the differences between clinical trial settings and general practice.” Yuwei Sun, MS, An analyst at the University of California, the Francis I. Proctor Foundation for Ophthalmic Research in San Francisco, and colleagues wrote. “The clinical trials had standardized protocols for vaccine storage, administration and herpes zoster diagnosis. In general practice, patients often have more comorbidities. “

Sun and colleagues conducted a retrospective cohort study of 4.7 million immunocompromised individuals of vaccine age using an unidentified harm database. A total of 173,745 adults received two doses of RZV.

The results showed that the herpes zoster incidence rate for those who received the vaccine was 258.8 cases per 100,000 person-years (95% CI, 230-289.4) and for those who were not vaccinated it was 893.1 per 100,000 person-years (95% CI) % CI, 886.2-900). Efficacy was 85.5% (95% CI, 83.5% -87.3%) overall, 86.8% (95% CI, 84.6% -88.7%) in patients over the age of 50 up to 79 years and 80.3% (95% CI, 75.1%) calculated% -84.3%) in patients over 80 years. In addition, efficacy was 84.8% (95% CI, 75.3% -90.7%) in patients who had a live herpes zoster vaccine within 5 years of enrollment in the study.

The authors noted that the limitations of the study included limited data for participants ages 50 to 59 and the inability to assess weight loss due to the analysis’s short follow-up.

“It will be of critical importance to identify potential barriers to future uptake of recombinant herpes zoster vaccines,” the authors write. “More research and health efforts are needed to identify and remove potential barriers to herpes zoster vaccination in order to protect more people from this common disease.”

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William Schaffner, MD)

William Schaffner, MD

As you move from a clinical trial to the real world, you wonder whether the results obtained in the clinical trial – in this case excellent results – are comparable to a real world environment. Clinical trials are a very sophisticated environment in which certain patients are excluded from participation. But in the real world, everyone gets the vaccine.

It is very comforting to see that this real-world data fully supports the excellent efficacy results achieved in the clinical trials. You should definitely encourage anyone 50 or older to get the RZV.

William Schaffner, MD

Member of the editorial team for infectious diseases

Medical Director of the National Infectious Diseases Foundation

Professor of Preventive Medicine and Infectious Diseases

Vanderbilt University Medical Center

Disclosure: Schaffner does not report any relevant financial information.

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