Infectious Disease

The new report offers the “most compelling” evidence yet of the effectiveness of COVID-19 vaccines

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Pilishvili does not report any relevant financial information. In the study you will find all relevant financial information from all other authors.

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Messenger RNA vaccines from Pfizer-BioNTech and Moderna were 94% effective at preventing symptomatic COVID-19 in healthcare workers after two doses and more than 80% effective according to one, researchers in MMWR reported.

The study – and others who like it – was “crucial” for the CDC to change its recommendations for people fully vaccinated against COVID-19, said CDC director Rochelle P. Walensky, MD, MPH.

Source: CDC.gov.

Source: CDC.gov.

Rochelle P. Walensky

“This report provided the most compelling information yet that COVID-19 vaccines are working as expected in the real world,” Walensky said in a statement.

After a relaxed guide to outdoor masks last month, the CDC said Thursday that fully vaccinated Americans no longer need to wear masks or social distancing themselves indoors, bringing the country back to a “sense of normal” after more than a year, it said Walensky.

In the new study Tamara Pilishvili, PhD, MPH, an epidemiologist at the CDC’s National Center for Immunization and Respiratory Diseases, and colleagues conducted a test-negative case-control study of the effectiveness of COVID-19 vaccines at 33 locations in 25 states from January through March. The study population comprised 623 case patients and 1,220 controls.

The calculated effectiveness of the vaccine after a single dose, measured 14 days after receiving the shot, was 82% (95% CI, 74% -87%). The effectiveness 7 days or more after the second dose was 94% (95% CI, 87% -97%).

On May 12, the CDC expanded its COVID-19 vaccine recommendations to include those ages 12-15 for the Pfizer BioNTech vaccine. Given the effectiveness of the vaccine, the CDC recommends people ages 12 and older get it.

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