HealthDay News – Approximately half of children with Pediatric Multisystem Inflammatory Syndrome, temporally associated with Severe Acute Respiratory Coronavirus 2 Syndrome (PIMS-TS), according to a study presented at the American Academy of Neurology’s annual meeting, emerging neurological symptoms on practically April 17-22.
Omar Abdel-Mannan, MD of Great Ormond Street Hospital in London and colleagues reported neurological manifestations in children with PIMS-TS. Data were included for 46 patients who presented during the study period (mean age 10.2 years).
The researchers found that 52.2 percent of children reported emerging neurological symptoms, including headache, encephalopathy, dysarthria / dysphonia, hallucinations, ataxia, peripheral nerve involvement, and seizures. One hundred and eighteen leukocytes were seen in a patient’s cerebral spine. Splenium signal changes on magnetic resonance imaging of the brain were found in four of 16 patients. 14 out of 15 children who had electroencephalography had excess slow activity, while four out of seven children who had nerve conduction studies and electromyography had myopathic and neuropathic changes. Higher peak markers of inflammation were seen in children with neurologic involvement and were more likely to be ventilated and need inotropic support in the pediatric intensive care unit.
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“Children who develop this condition should definitely be evaluated for neurological symptoms and longer-term cognitive outcomes,” Abdel-Mannan said in a statement. “More studies, involving more children and subsequent children, are needed to see how this condition changes over time and whether there are longer-term neurocognitive effects.”
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Subjects:
COVID19 General Neurology Pediatric Neurology
